Toward an understanding of the correlates of protective immunity to HIV infection.


Journal Article (Review)

Considerable progress has been made recently in understanding the genetic, immunologic and virologic factors in human immunodeficiency virus (HIV)-infected individuals who either rapidly progress or do not progress to acquired immunodeficiency syndrome (AIDS). In addition, detection of HIV-specific immune responses in HIV-negative individuals who have been exposed to the virus multiple times suggests that natural immune responses to HIV may be protective in rare individuals. Understanding the correlates of protective immunity to HIV infection is critical to efforts to develop preventive HIV vaccines as well as to determine the feasibility of treating HIV infection by boosting immunity to HIV.

Full Text

Duke Authors

Cited Authors

  • Haynes, BF; Pantaleo, G; Fauci, AS

Published Date

  • January 19, 1996

Published In

Volume / Issue

  • 271 / 5247

Start / End Page

  • 324 - 328

PubMed ID

  • 8553066

Pubmed Central ID

  • 8553066

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.271.5247.324


  • eng

Conference Location

  • United States