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Cytokines and adhesion molecules in the pathogenesis of vasculitis.

Publication ,  Journal Article
Sundy, JS; Haynes, BF
Published in: Curr Rheumatol Rep
October 2000

Upregulated adhesion molecule and cytokine expression on endothelial cells and infiltrating inflammatory cells occur in most vasculitis syndromes. These observations suggest that vasculitis is associated with pathologic activation of normal immune cell cytokine cascades. Abnormal expression of adhesion molecules and cytokines in vascular endothelium is a manifestation of endothelial dysfunction that can be triggered by a variety of stimuli, including infectious agents, immune complexes, and antiendothelial cell antibodies. Dysregulated adhesion molecule expression, uncontrolled inflammation, thrombosis, and vessel occlusion lead to the clinical manifestations of vasculitis.

Duke Scholars

Published In

Curr Rheumatol Rep

DOI

ISSN

1523-3774

Publication Date

October 2000

Volume

2

Issue

5

Start / End Page

402 / 410

Location

United States

Related Subject Headings

  • Vasculitis
  • Up-Regulation
  • Syndrome
  • Severity of Illness Index
  • Sensitivity and Specificity
  • Prognosis
  • Male
  • Humans
  • Female
  • Cytokines
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Sundy, J. S., & Haynes, B. F. (2000). Cytokines and adhesion molecules in the pathogenesis of vasculitis. Curr Rheumatol Rep, 2(5), 402–410. https://doi.org/10.1007/s11926-000-0040-8
Sundy, J. S., and B. F. Haynes. “Cytokines and adhesion molecules in the pathogenesis of vasculitis.Curr Rheumatol Rep 2, no. 5 (October 2000): 402–10. https://doi.org/10.1007/s11926-000-0040-8.
Sundy JS, Haynes BF. Cytokines and adhesion molecules in the pathogenesis of vasculitis. Curr Rheumatol Rep. 2000 Oct;2(5):402–10.
Sundy, J. S., and B. F. Haynes. “Cytokines and adhesion molecules in the pathogenesis of vasculitis.Curr Rheumatol Rep, vol. 2, no. 5, Oct. 2000, pp. 402–10. Pubmed, doi:10.1007/s11926-000-0040-8.
Sundy JS, Haynes BF. Cytokines and adhesion molecules in the pathogenesis of vasculitis. Curr Rheumatol Rep. 2000 Oct;2(5):402–410.
Journal cover image

Published In

Curr Rheumatol Rep

DOI

ISSN

1523-3774

Publication Date

October 2000

Volume

2

Issue

5

Start / End Page

402 / 410

Location

United States

Related Subject Headings

  • Vasculitis
  • Up-Regulation
  • Syndrome
  • Severity of Illness Index
  • Sensitivity and Specificity
  • Prognosis
  • Male
  • Humans
  • Female
  • Cytokines