The human thymus during aging.
Publication
, Journal Article
Haynes, BF; Sempowski, GD; Wells, AF; Hale, LP
Published in: Immunol Res
2000
The human thymus is required for establishment of a normal T cell repertoire in fetal development, as children born without a thymus (DiGeorge Syndrome) lack thymus-derived (T) and T cell immunity. While the function of the thymus in children for production of new T cells is clear, it has not been obvious that the adult thymus can produce significant numbers of new T cells. Until recently, no assays were available to directly evaluate postnatal thymic function. This paper reviews work on human thymic aging at Duke University School of Medicine and discusses the relevance of this work to devising new strategies for T cell immune reconstitution in man.
Duke Scholars
Published In
Immunol Res
DOI
ISSN
0257-277X
Publication Date
2000
Volume
22
Issue
2-3
Start / End Page
253 / 261
Location
United States
Related Subject Headings
- Thymus Gland
- Myasthenia Gravis
- Immunology
- Humans
- Cytokines
- Animals
- Aging
- Age Factors
- Adult
- 3204 Immunology
Citation
APA
Chicago
ICMJE
MLA
NLM
Haynes, B. F., Sempowski, G. D., Wells, A. F., & Hale, L. P. (2000). The human thymus during aging. Immunol Res, 22(2–3), 253–261. https://doi.org/10.1385/IR:22:2-3:253
Haynes, B. F., G. D. Sempowski, A. F. Wells, and L. P. Hale. “The human thymus during aging.” Immunol Res 22, no. 2–3 (2000): 253–61. https://doi.org/10.1385/IR:22:2-3:253.
Haynes BF, Sempowski GD, Wells AF, Hale LP. The human thymus during aging. Immunol Res. 2000;22(2–3):253–61.
Haynes, B. F., et al. “The human thymus during aging.” Immunol Res, vol. 22, no. 2–3, 2000, pp. 253–61. Pubmed, doi:10.1385/IR:22:2-3:253.
Haynes BF, Sempowski GD, Wells AF, Hale LP. The human thymus during aging. Immunol Res. 2000;22(2–3):253–261.
Published In
Immunol Res
DOI
ISSN
0257-277X
Publication Date
2000
Volume
22
Issue
2-3
Start / End Page
253 / 261
Location
United States
Related Subject Headings
- Thymus Gland
- Myasthenia Gravis
- Immunology
- Humans
- Cytokines
- Animals
- Aging
- Age Factors
- Adult
- 3204 Immunology