Phenotypic characterization of human bone marrow granulocyte-macrophage forming progenitor cells.

Journal Article (Journal Article)

Cell surface antigens of the human bone marrow CFU-C have been studied. Human marrow cells were incubated with a variety of monoclonal antisera and complement prior to culture in semisolid media. By using indirect immunofluorescent studies, the percentage of bone marrow cells binding the antibodies was determined. The CFU-C phenotype is HLA+, la+, 4F2+, 3A1-, and DUALL-1-. This study provides information that is useful in the study of myeloid cell ontogeny and necessary for the use of some of these reagents in the treatment of bone marrow cells prior to human bone marrow transplantation in various clinical settings.

Full Text

Duke Authors

Cited Authors

  • Levine, MN; Fay, JW; Jones, NH; Metzgar, RS; Haynes, BF

Published Date

  • November 1, 1981

Published In

Volume / Issue

  • 58 / 5

Start / End Page

  • 1047 - 1049

PubMed ID

  • 6945879

International Standard Serial Number (ISSN)

  • 0006-4971


  • eng

Conference Location

  • United States