Rheumatoid arthritis and sterile corneal ulceration. Analysis of tissue immune effector cells and ocular epithelial antigens using monoclonal antibodies.

Journal Article

Tissue immune effector cells and epithelial surface antigens present in eye tissue of rheumatoid arthritis (RA) patients with sterile corneal ulceration were studied using a large panel of monoclonal antibodies. During periods of active corneal ulceration, conjunctivae and corneas of all RA patients studied contained numerous immune-associated (Ia) antigen-positive tissue macrophages. In 4 of 6 patients, conjunctival or corneal T cell infiltrations were present. In 2 patients, a T cell vasculitis was seen in conjunctival tissue. Conjunctival epithelial cells of all 6 RA patients expressed Ia antigens during active corneal ulceration. These data provide evidence for immune-mediated mechanisms in the pathophysiology of corneal ulceration in RA. Moreover, the expression of Ia antigens by conjunctival epithelial cells may be a useful indicator of disease activity in RA patients with sterile corneal ulceration.

Full Text

Duke Authors

Cited Authors

  • Michels, ML; Cobo, LM; Caldwell, DS; Rice, JR; Haynes, BF

Published Date

  • June 1, 1984

Published In

Volume / Issue

  • 27 / 6

Start / End Page

  • 606 - 614

PubMed ID

  • 6233985

International Standard Serial Number (ISSN)

  • 0004-3591

Language

  • eng

Conference Location

  • United States