Review of chronic graft-versus-host disease in children after allogeneic stem cell transplantation: nursing perspective.

Published

Journal Article (Review)

This review presents a summary of the research literature related to the incidence and risk factors for chronic graft-versus-host disease in children following allogeneic hematopoietic stem cell transplantation. The range of incidence of chronic graft-versus-host disease in children found in this review was large, from 0% to 46%. Incidence of chronic graft-versus-host disease was influenced by sample size, time posttransplantation, and stem cell source. Characteristics of the person (eg, child's age and gender) and disease/treatment (eg, sources of transplant) are associated with chronic graft-versus-host disease in children after stem cell transplantation. Person and disease/treatment characteristics provide a framework for understanding the factors associated with chronic graft-versus-host disease symptom experiences in children after stem cell transplantation. Timely assessment of presenting chronic graft-versus-host disease symptoms is critical for treatment and prognosis. Nursing interventions should focus on educating children and parents about the signs and symptoms of chronic graft-versus-host disease. The summary of supportive nursing care for children with chronic graft-versus-host disease provides important information to tailor effective management strategies for children with chronic graft-versus-host disease.

Full Text

Duke Authors

Cited Authors

  • Liu, Y-M; Hockenberry, M

Published Date

  • January 2011

Published In

Volume / Issue

  • 28 / 1

Start / End Page

  • 6 - 15

PubMed ID

  • 20841443

Pubmed Central ID

  • 20841443

Electronic International Standard Serial Number (EISSN)

  • 1532-8457

International Standard Serial Number (ISSN)

  • 1043-4542

Digital Object Identifier (DOI)

  • 10.1177/1043454210377177

Language

  • eng