Reducing central venous catheter-related bloodstream infections in children with cancer.

Journal Article (Journal Article)


To determine whether a comprehensive educational program influenced the incidence of hub colonization of central venous catheters (CVCs) and bloodstream infection rates in children with cancer, to identify risk factors related to infection rates, and to determine the impact of an educational program on nurses' knowledge of CVC care for children with cancer.


Prospective, longitudinal.


Pediatric cancer center in a large children's hospital in the southwestern United States.


51 catheter hub cultures were obtained from 27 children with cancer, and 121 nurses participated in the educational intervention.


CVC hub cultures were obtained prior to and three months after an educational intervention. A written pre- and posteducation assessment was used to evaluate the nurses' learning.

Main research variables

Hub colonization and bloodstream infection rates.


Post-test mean score of 87% was significantly higher than the pretest mean score of 72%. Prior to the education program, 57% of the hubs were culture positive, and after the educational program, the proportion of culture-positive hubs was reduced to 36%.


A comprehensive educational program increases nurses' knowledge of CVC care and reduces CVC hub colonization and catheter-related bloodstream infections in children with cancer.

Implications for nursing

Patient and family participation in practice changes is very important because they have the most to gain. Additional research evaluating the relationship between hub colonization and subsequent bloodstream infection in a larger sample is warranted.

Full Text

Duke Authors

Cited Authors

  • Horvath, B; Norville, R; Lee, D; Hyde, A; Gregurich, M; Hockenberry, M

Published Date

  • March 2009

Published In

Volume / Issue

  • 36 / 2

Start / End Page

  • 232 - 238

PubMed ID

  • 19273413

Electronic International Standard Serial Number (EISSN)

  • 1538-0688

International Standard Serial Number (ISSN)

  • 0190-535X

Digital Object Identifier (DOI)

  • 10.1188/09.onf.232-238


  • eng