Brief report: Effect of intravenous methotrexate dose and infusion rate on neuropsychological function one year after diagnosis of acute lymphoblastic leukemia

Journal Article

Objective: To compare the effects of two intravenous (IV) methotrexate (MTX) infusion protocols on cognitive function in children newly diagnosed with acute lymphoblastic leukemia (ALL). Methods: We compared 19 children treated with 1 g/m2 of IV MTX over 24 hr (Group 1) to 13 children treated with 2 g/m2 of IV MTX over 4 hr (Group 2) on measures of working memory, nonverbal, and verbal skills shortly after diagnosis (Time 1) and 1 year later (Time 2). Results: A significant Group×Time interaction was found for a composite measure of working memory with Group 2 declining from Time 1 to Time 2. Group 2 performed significantly worse than Group 1 on a composite measure of nonverbal skills at both time points. Conclusions: Findings suggest that difficulties in working memory and nonverbal skills may be evident during the first year of treatment for ALL and that severity may be dependent on IV MTX dose and/or infusion rate. © The Author 2006. Published by Oxford University Press on behalf of the Society of Pediatric Psychology.

Full Text

Duke Authors

Cited Authors

  • Carey, ME; Hockenberry, MJ; Moore, IM; Hutter, JJ; Krull, KR; Pasvogel, A; Kaemingk, KL

Published Date

  • 2007

Published In

Volume / Issue

  • 32 / 2

Start / End Page

  • 189 - 193

PubMed ID

  • 16675716

International Standard Serial Number (ISSN)

  • 0146-8693

Digital Object Identifier (DOI)

  • 10.1093/jpepsy/jsj114