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Long-term memory B-cell responses in recipients of candidate human immunodeficiency virus type 1 vaccines.

Publication ,  Journal Article
Evans, TG; Frey, S; Israel, H; Chiu, J; El-Habib, R; Gilbert, P; Gaitan, A; Montefiori, DC; HIV Vaccine Trials Network (HVTN 803),
Published in: Vaccine
June 30, 2004

The efficacy and practical application of human immunodeficiency virus type 1 (HIV-1) vaccines may depend in part on the longevity of the immune responses generated, particularly those in the memory compartment. Candidate vaccines based on the HIV-1 envelope glycoproteins generate binding and neutralizing antibodies in humans but there have been no prior studies on the long-term persistence and recall of those responses. We evaluated six healthy, HIV non-infected adults who had received a combination of recombinant canarypox HIV-1 vaccines boosted by gp120 and who had achieved a high serum titer of neutralizing antibody to HIV-1 MN. These individuals were administered a gp160 boost 4-5 years after their last vaccination. Four volunteers had detectable binding and neutralizing antibodies at the time of boosting and all six volunteers exhibited a recall binding and neutralizing antibody response. The antibodies neutralized multiple T cell line-adapted (TCLA) strains of virus, including the vaccine strain, but not primary isolates. These results demonstrate that memory B-cell responses can last for many years following HIV-1 envelope glycoprotein immunization. In principle, similar long-term memory may be possible with improved immunogens that generate broadly cross-reactive neutralizing antibodies.

Duke Scholars

Published In

Vaccine

DOI

ISSN

0264-410X

Publication Date

June 30, 2004

Volume

22

Issue

20

Start / End Page

2626 / 2630

Location

Netherlands

Related Subject Headings

  • Virology
  • Vaccines, Synthetic
  • Immunologic Memory
  • Humans
  • HIV-1
  • HIV Envelope Protein gp160
  • HIV Antibodies
  • B-Lymphocytes
  • Adult
  • Acquired Immunodeficiency Syndrome
 

Citation

APA
Chicago
ICMJE
MLA
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Evans, T. G., Frey, S., Israel, H., Chiu, J., El-Habib, R., Gilbert, P., … HIV Vaccine Trials Network (HVTN 803), . (2004). Long-term memory B-cell responses in recipients of candidate human immunodeficiency virus type 1 vaccines. Vaccine, 22(20), 2626–2630. https://doi.org/10.1016/j.vaccine.2003.12.011
Evans, Thomas G., Sharon Frey, Heidi Israel, Joseph Chiu, Raphaelle El-Habib, Peter Gilbert, Alicia Gaitan, David C. Montefiori, and David C. HIV Vaccine Trials Network (HVTN 803). “Long-term memory B-cell responses in recipients of candidate human immunodeficiency virus type 1 vaccines.Vaccine 22, no. 20 (June 30, 2004): 2626–30. https://doi.org/10.1016/j.vaccine.2003.12.011.
Evans TG, Frey S, Israel H, Chiu J, El-Habib R, Gilbert P, et al. Long-term memory B-cell responses in recipients of candidate human immunodeficiency virus type 1 vaccines. Vaccine. 2004 Jun 30;22(20):2626–30.
Evans, Thomas G., et al. “Long-term memory B-cell responses in recipients of candidate human immunodeficiency virus type 1 vaccines.Vaccine, vol. 22, no. 20, June 2004, pp. 2626–30. Pubmed, doi:10.1016/j.vaccine.2003.12.011.
Evans TG, Frey S, Israel H, Chiu J, El-Habib R, Gilbert P, Gaitan A, Montefiori DC, HIV Vaccine Trials Network (HVTN 803). Long-term memory B-cell responses in recipients of candidate human immunodeficiency virus type 1 vaccines. Vaccine. 2004 Jun 30;22(20):2626–2630.
Journal cover image

Published In

Vaccine

DOI

ISSN

0264-410X

Publication Date

June 30, 2004

Volume

22

Issue

20

Start / End Page

2626 / 2630

Location

Netherlands

Related Subject Headings

  • Virology
  • Vaccines, Synthetic
  • Immunologic Memory
  • Humans
  • HIV-1
  • HIV Envelope Protein gp160
  • HIV Antibodies
  • B-Lymphocytes
  • Adult
  • Acquired Immunodeficiency Syndrome