Effects of cytotoxic T lymphocytes (CTL) directed against a single simian immunodeficiency virus (SIV) Gag CTL epitope on the course of SIVmac239 infection.


Journal Article

Vaccine-induced cytotoxic T lymphocytes (CTL) have been implicated in the control of virus replication in simian immunodeficiency virus (SIV)-challenged and simian-human immunodeficiency virus-challenged macaques. Therefore, we wanted to test the impact that vaccine-induced CTL responses against an immunodominant Gag epitope might have in the absence of other immune responses. By themselves, these strong CTL responses failed to control SIVmac239 replication.

Full Text

Duke Authors

Cited Authors

  • Allen, TM; Jing, P; Calore, B; Horton, H; O'Connor, DH; Hanke, T; Piekarczyk, M; Ruddersdorf, R; Mothé, BR; Emerson, C; Wilson, N; Lifson, JD; Belyakov, IM; Berzofsky, JA; Wang, C; Allison, DB; Montefiori, DC; Desrosiers, RC; Wolinsky, S; Kunstman, KJ; Altman, JD; Sette, A; McMichael, AJ; Watkins, DI

Published Date

  • October 2002

Published In

Volume / Issue

  • 76 / 20

Start / End Page

  • 10507 - 10511

PubMed ID

  • 12239328

Pubmed Central ID

  • 12239328

International Standard Serial Number (ISSN)

  • 0022-538X

Digital Object Identifier (DOI)

  • 10.1128/jvi.76.20.10507-10511.2002


  • eng

Conference Location

  • United States