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Increased loss of CCR5+ CD45RA- CD4+ T cells in CD8+ lymphocyte-depleted Simian immunodeficiency virus-infected rhesus monkeys.

Publication ,  Journal Article
Veazey, RS; Acierno, PM; McEvers, KJ; Baumeister, SHC; Foster, GJ; Rett, MD; Newberg, MH; Kuroda, MJ; Williams, K; Kim, E-Y; Wolinsky, SM ...
Published in: J Virol
June 2008

Previously we have shown that CD8(+) T cells are critical for containment of simian immunodeficiency virus (SIV) viremia and that rapid and profound depletion of CD4(+) T cells occurs in the intestinal tract of acutely infected macaques. To determine the impact of SIV-specific CD8(+) T-cell responses on the magnitude of the CD4(+) T-cell depletion, we investigated the effect of CD8(+) lymphocyte depletion during primary SIV infection on CD4(+) T-cell subsets and function in peripheral blood, lymph nodes, and intestinal tissues. In peripheral blood, CD8(+) lymphocyte-depletion changed the dynamics of CD4(+) T-cell loss, resulting in a more pronounced loss 2 weeks after infection, followed by a temporal rebound approximately 2 months after infection, when absolute numbers of CD4(+) T cells were restored to baseline levels. These CD4(+) T cells showed a markedly skewed phenotype, however, as there were decreased levels of memory cells in CD8(+) lymphocyte-depleted macaques compared to controls. In intestinal tissues and lymph nodes, we observed a significantly higher loss of CCR5(+) CD45RA(-) CD4(+) T cells in CD8(+) lymphocyte-depleted macaques than in controls, suggesting that these SIV-targeted CD4(+) T cells were eliminated more efficiently in CD8(+) lymphocyte-depleted animals. Also, CD8(+) lymphocyte depletion significantly affected the ability to generate SIV Gag-specific CD4(+) T-cell responses and neutralizing antibodies. These results reemphasize that SIV-specific CD8(+) T-cell responses are absolutely critical to initiate at least partial control of SIV infection.

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Published In

J Virol

DOI

EISSN

1098-5514

Publication Date

June 2008

Volume

82

Issue

11

Start / End Page

5618 / 5630

Location

United States

Related Subject Headings

  • Virus Replication
  • Virology
  • Survival Rate
  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Simian Acquired Immunodeficiency Syndrome
  • Receptors, CCR5
  • Male
  • Macaca mulatta
  • Lymph Nodes
 

Citation

APA
Chicago
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MLA
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Veazey, R. S., Acierno, P. M., McEvers, K. J., Baumeister, S. H. C., Foster, G. J., Rett, M. D., … Schmitz, J. E. (2008). Increased loss of CCR5+ CD45RA- CD4+ T cells in CD8+ lymphocyte-depleted Simian immunodeficiency virus-infected rhesus monkeys. J Virol, 82(11), 5618–5630. https://doi.org/10.1128/JVI.02748-07
Veazey, Ronald S., Paula M. Acierno, Kimberly J. McEvers, Susanne H. C. Baumeister, Gabriel J. Foster, Melisa D. Rett, Michael H. Newberg, et al. “Increased loss of CCR5+ CD45RA- CD4+ T cells in CD8+ lymphocyte-depleted Simian immunodeficiency virus-infected rhesus monkeys.J Virol 82, no. 11 (June 2008): 5618–30. https://doi.org/10.1128/JVI.02748-07.
Veazey RS, Acierno PM, McEvers KJ, Baumeister SHC, Foster GJ, Rett MD, et al. Increased loss of CCR5+ CD45RA- CD4+ T cells in CD8+ lymphocyte-depleted Simian immunodeficiency virus-infected rhesus monkeys. J Virol. 2008 Jun;82(11):5618–30.
Veazey, Ronald S., et al. “Increased loss of CCR5+ CD45RA- CD4+ T cells in CD8+ lymphocyte-depleted Simian immunodeficiency virus-infected rhesus monkeys.J Virol, vol. 82, no. 11, June 2008, pp. 5618–30. Pubmed, doi:10.1128/JVI.02748-07.
Veazey RS, Acierno PM, McEvers KJ, Baumeister SHC, Foster GJ, Rett MD, Newberg MH, Kuroda MJ, Williams K, Kim E-Y, Wolinsky SM, Rieber EP, Piatak M, Lifson JD, Montefiori DC, Brown CR, Hirsch VM, Schmitz JE. Increased loss of CCR5+ CD45RA- CD4+ T cells in CD8+ lymphocyte-depleted Simian immunodeficiency virus-infected rhesus monkeys. J Virol. 2008 Jun;82(11):5618–5630.

Published In

J Virol

DOI

EISSN

1098-5514

Publication Date

June 2008

Volume

82

Issue

11

Start / End Page

5618 / 5630

Location

United States

Related Subject Headings

  • Virus Replication
  • Virology
  • Survival Rate
  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Simian Acquired Immunodeficiency Syndrome
  • Receptors, CCR5
  • Male
  • Macaca mulatta
  • Lymph Nodes