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Passive immunotherapy in simian immunodeficiency virus-infected macaques accelerates the development of neutralizing antibodies.

Publication ,  Journal Article
Haigwood, NL; Montefiori, DC; Sutton, WF; McClure, J; Watson, AJ; Voss, G; Hirsch, VM; Richardson, BA; Letvin, NL; Hu, S-L; Johnson, PR
Published in: J Virol
June 2004

Passively transferred neutralizing antibodies can block lentivirus infection, but their role in postexposure prophylaxis is poorly understood. In this nonhuman-primate study, the effects of short-term antibody therapy on 5-year disease progression, virus load, and host immunity were explored. We reported previously that postinfection passive treatment with polyclonal immune globulin with high neutralizing titers against SIVsmE660 (SIVIG) significantly improved the 67-week health of SIVsmE660-infected Macaca mulatta macaques. Four of six treated macaques maintained low or undetectable levels of virus in plasma, compared with one of ten controls, while two rapid progressors controlled viremia only as long as the SIVIG was present. SIVIG treatment delayed the de novo production of envelope (Env)-specific antibodies by 8 weeks (13). We show here that differences in disease progression were also significant at 5 years postinfection, excluding rapid progressors (P = 0.05). Macaques that maintained

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Published In

J Virol

DOI

ISSN

0022-538X

Publication Date

June 2004

Volume

78

Issue

11

Start / End Page

5983 / 5995

Location

United States

Related Subject Headings

  • Virology
  • Viremia
  • T-Lymphocytes, Cytotoxic
  • Simian Acquired Immunodeficiency Syndrome
  • Neutralization Tests
  • Macaca mulatta
  • Lymph Nodes
  • Immunoglobulin G
  • Immunization, Passive
  • Gene Products, gag
 

Citation

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Haigwood, N. L., Montefiori, D. C., Sutton, W. F., McClure, J., Watson, A. J., Voss, G., … Johnson, P. R. (2004). Passive immunotherapy in simian immunodeficiency virus-infected macaques accelerates the development of neutralizing antibodies. J Virol, 78(11), 5983–5995. https://doi.org/10.1128/JVI.78.11.5983-5995.2004
Haigwood, Nancy L., David C. Montefiori, William F. Sutton, Janela McClure, Andrew J. Watson, Gerald Voss, Vanessa M. Hirsch, et al. “Passive immunotherapy in simian immunodeficiency virus-infected macaques accelerates the development of neutralizing antibodies.J Virol 78, no. 11 (June 2004): 5983–95. https://doi.org/10.1128/JVI.78.11.5983-5995.2004.
Haigwood NL, Montefiori DC, Sutton WF, McClure J, Watson AJ, Voss G, et al. Passive immunotherapy in simian immunodeficiency virus-infected macaques accelerates the development of neutralizing antibodies. J Virol. 2004 Jun;78(11):5983–95.
Haigwood, Nancy L., et al. “Passive immunotherapy in simian immunodeficiency virus-infected macaques accelerates the development of neutralizing antibodies.J Virol, vol. 78, no. 11, June 2004, pp. 5983–95. Pubmed, doi:10.1128/JVI.78.11.5983-5995.2004.
Haigwood NL, Montefiori DC, Sutton WF, McClure J, Watson AJ, Voss G, Hirsch VM, Richardson BA, Letvin NL, Hu S-L, Johnson PR. Passive immunotherapy in simian immunodeficiency virus-infected macaques accelerates the development of neutralizing antibodies. J Virol. 2004 Jun;78(11):5983–5995.

Published In

J Virol

DOI

ISSN

0022-538X

Publication Date

June 2004

Volume

78

Issue

11

Start / End Page

5983 / 5995

Location

United States

Related Subject Headings

  • Virology
  • Viremia
  • T-Lymphocytes, Cytotoxic
  • Simian Acquired Immunodeficiency Syndrome
  • Neutralization Tests
  • Macaca mulatta
  • Lymph Nodes
  • Immunoglobulin G
  • Immunization, Passive
  • Gene Products, gag