IL-12/GM-CSF coadministration in an SIV DNA prime/protein boost protocol enhances Gag-specific T cells but not virus-specific neutralizing antibodies in rhesus macaques.
Journal Article (Journal Article)
Coadministration of pVecB7, a replication-defective SIV DNA vaccine, with interleukin-12 and GM-CSF expression plasmids, induced markedly enhanced control of viral replication and disease-free survival in macaques challenged intrarectally with pathogenic SIVsmE660. Protective mechanisms correlated with broader cell-mediated immune responses to the first two-thirds of the SIV Gag protein and possibly with enhanced SIVsmE660 antibody neutralization at set point, but not with pre- or early postchallenge SIVsmE660 neutralizing antibody production.
- O'Neill, E; Bostik, V; Montefiori, DC; Kraiselburd, E; Villinger, F
- October 1, 2003
Volume / Issue
- 19 / 10
Start / End Page
- 883 - 890
International Standard Serial Number (ISSN)
Digital Object Identifier (DOI)
- United States