IL-12/GM-CSF coadministration in an SIV DNA prime/protein boost protocol enhances Gag-specific T cells but not virus-specific neutralizing antibodies in rhesus macaques.

Published

Journal Article

Coadministration of pVecB7, a replication-defective SIV DNA vaccine, with interleukin-12 and GM-CSF expression plasmids, induced markedly enhanced control of viral replication and disease-free survival in macaques challenged intrarectally with pathogenic SIVsmE660. Protective mechanisms correlated with broader cell-mediated immune responses to the first two-thirds of the SIV Gag protein and possibly with enhanced SIVsmE660 antibody neutralization at set point, but not with pre- or early postchallenge SIVsmE660 neutralizing antibody production.

Full Text

Duke Authors

Cited Authors

  • O'Neill, E; Bostik, V; Montefiori, DC; Kraiselburd, E; Villinger, F

Published Date

  • October 1, 2003

Published In

Volume / Issue

  • 19 / 10

Start / End Page

  • 883 - 890

PubMed ID

  • 14585220

Pubmed Central ID

  • 14585220

International Standard Serial Number (ISSN)

  • 0889-2229

Digital Object Identifier (DOI)

  • 10.1089/088922203322493058

Language

  • eng

Conference Location

  • United States