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Rapid SIV Env-specific mucosal and serum antibody induction augments cellular immunity in protecting immunized, elite-controller macaques against high dose heterologous SIV challenge.

Publication ,  Journal Article
Patterson, LJ; Daltabuit-Test, M; Xiao, P; Zhao, J; Hu, W; Wille-Reece, U; Brocca-Cofano, E; Kalyanaraman, VS; Kalisz, I; Whitney, S; Lee, EM ...
Published in: Virology
March 1, 2011

Three Indian rhesus macaques, Ad-SIV primed/protein boosted and exposed twice to high-dose mucosal SIV(mac251) challenges, exhibited elite control of viremia over 6.5 years. They were negative for host factors associated with control of SIV infection. After a third intrarectal challenge with SIV(smE660), all controlled viremia, with one (macaque #5) maintaining undetectable viremia in blood. Acquisition was not blocked, but virus was contained in the jejunum and draining lymph nodes. Polyfunctional memory T cell responses and high-titered neutralizing and non-neutralizing serum and mucosal antibodies were present before and maintained post-challenge. The level of protection seen for animal #5 was predicted from analyses of gene transcription in jejunum 2 weeks post-challenge. Macaques #7 and #9, exhibiting lower pre-challenge cellular and humoral immunity, partially controlled the SIV(smE660) challenge. Initial vaccine-induced control by macaque #5 extended to the SIV(smE660) challenge due to multiple immune mechanisms that were boosted and augmented by cryptic SIV exposure.

Duke Scholars

Published In

Virology

DOI

EISSN

1096-0341

Publication Date

March 1, 2011

Volume

411

Issue

1

Start / End Page

87 / 102

Location

United States

Related Subject Headings

  • Virology
  • Viremia
  • T-Lymphocytes
  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Simian Acquired Immunodeficiency Syndrome
  • Serum
  • Macaca mulatta
  • Lymph Nodes
  • Jejunum
 

Citation

APA
Chicago
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MLA
NLM
Patterson, L. J., Daltabuit-Test, M., Xiao, P., Zhao, J., Hu, W., Wille-Reece, U., … Robert-Guroff, M. (2011). Rapid SIV Env-specific mucosal and serum antibody induction augments cellular immunity in protecting immunized, elite-controller macaques against high dose heterologous SIV challenge. Virology, 411(1), 87–102. https://doi.org/10.1016/j.virol.2010.12.033
Patterson, L Jean, Mara Daltabuit-Test, Peng Xiao, Jun Zhao, William Hu, Ulrike Wille-Reece, Egidio Brocca-Cofano, et al. “Rapid SIV Env-specific mucosal and serum antibody induction augments cellular immunity in protecting immunized, elite-controller macaques against high dose heterologous SIV challenge.Virology 411, no. 1 (March 1, 2011): 87–102. https://doi.org/10.1016/j.virol.2010.12.033.
Patterson, L. Jean, et al. “Rapid SIV Env-specific mucosal and serum antibody induction augments cellular immunity in protecting immunized, elite-controller macaques against high dose heterologous SIV challenge.Virology, vol. 411, no. 1, Mar. 2011, pp. 87–102. Pubmed, doi:10.1016/j.virol.2010.12.033.
Patterson LJ, Daltabuit-Test M, Xiao P, Zhao J, Hu W, Wille-Reece U, Brocca-Cofano E, Kalyanaraman VS, Kalisz I, Whitney S, Lee EM, Pal R, Montefiori DC, Dandekar S, Seder R, Roederer M, Wiseman RW, Hirsch V, Robert-Guroff M. Rapid SIV Env-specific mucosal and serum antibody induction augments cellular immunity in protecting immunized, elite-controller macaques against high dose heterologous SIV challenge. Virology. 2011 Mar 1;411(1):87–102.
Journal cover image

Published In

Virology

DOI

EISSN

1096-0341

Publication Date

March 1, 2011

Volume

411

Issue

1

Start / End Page

87 / 102

Location

United States

Related Subject Headings

  • Virology
  • Viremia
  • T-Lymphocytes
  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Simian Acquired Immunodeficiency Syndrome
  • Serum
  • Macaca mulatta
  • Lymph Nodes
  • Jejunum