Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine.
Heterologous prime/boost regimens have the potential for raising high levels of immune responses. Here, we report that DNA priming followed by a recombinant modified vaccinia Ankara (rMVA) booster has controlled a highly pathogenic immunodeficiency virus challenge in a Rhesus macaque model. Both the DNA and rMVA components of the vaccine expressed multiple immunodeficiency virus proteins. Two DNA inoculations at 0 and 8 weeks and a single rMVA booster at 24 weeks effectively controlled an intrarectal challenge administered 7 months after the booster. These highly promising findings provide hope that a relatively simple multiprotein DNA/MVA vaccine can help to control the AIDS epidemic.
Amara, RR; Villinger, F; Altman, JD; Lydy, SL; O'Neil, SP; Staprans, SI; Montefiori, DC; Xu, Y; Herndon, JG; Wyatt, LS; Candido, MA; Kozyr, NL; Earl, PL; Smith, JM; Ma, H-L; Grimm, BD; Hulsey, ML; McClure, HM; McNicholl, JM; Moss, B; Robinson, HL
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