Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine.

Journal Article (Journal Article;Review)

Heterologous prime/boost regimens have the potential for raising high levels of immune responses. Here, we report that DNA priming followed by a recombinant modified vaccinia Ankara (rMVA) booster has controlled a highly pathogenic immunodeficiency virus challenge in a Rhesus macaque model. Both the DNA and rMVA components of the vaccine expressed multiple immunodeficiency virus proteins. Two DNA inoculations at 0 and 8 weeks and a single rMVA booster at 24 weeks effectively controlled an intrarectal challenge administered 7 months after the booster. These highly promising findings provide hope that a relatively simple multiprotein DNA/MVA vaccine can help to control the AIDS epidemic.

Full Text

Duke Authors

Cited Authors

  • Amara, RR; Villinger, F; Altman, JD; Lydy, SL; O'Neil, SP; Staprans, SI; Montefiori, DC; Xu, Y; Herndon, JG; Wyatt, LS; Candido, MA; Kozyr, NL; Earl, PL; Smith, JM; Ma, H-L; Grimm, BD; Hulsey, ML; McClure, HM; McNicholl, JM; Moss, B; Robinson, HL

Published Date

  • May 6, 2002

Published In

Volume / Issue

  • 20 / 15

Start / End Page

  • 1949 - 1955

PubMed ID

  • 11983252

International Standard Serial Number (ISSN)

  • 0264-410X

Digital Object Identifier (DOI)

  • 10.1016/s0264-410x(02)00076-2


  • eng

Conference Location

  • Netherlands