Protective efficacy of a single immunization of a chimeric adenovirus vector-based vaccine against simian immunodeficiency virus challenge in rhesus monkeys.

Published

Journal Article

Rare serotype and chimeric recombinant adenovirus (rAd) vectors that evade anti-Ad5 immunity are currently being evaluated as potential vaccine vectors for human immunodeficiency virus type 1 and other pathogens. We have recently reported that a heterologous rAd prime-boost regimen expressing simian immunodeficiency virus (SIV) Gag afforded durable partial immune control of an SIV challenge in rhesus monkeys. However, single-shot immunization may ultimately be preferable for global vaccine delivery. We therefore evaluated the immunogenicity and protective efficacy of a single immunization of chimeric rAd5 hexon hypervariable region 48 (rAd5HVR48) vectors expressing SIV Gag, Pol, Nef, and Env against a homologous SIV challenge in rhesus monkeys. Inclusion of Env resulted in improved control of peak and set point SIV RNA levels following challenge. In contrast, DNA vaccine priming did not further improve the protective efficacy of rAd5HVR48 vectors in this system.

Full Text

Duke Authors

Cited Authors

  • Barouch, DH; Liu, J; Lynch, DM; O'Brien, KL; La Porte, A; Simmons, NL; Riggs, AM; Clark, S; Abbink, P; Montefiori, DC; Landucci, G; Forthal, DN; Self, SG; Carville, A; Mansfield, K; Goudsmit, J

Published Date

  • September 2009

Published In

Volume / Issue

  • 83 / 18

Start / End Page

  • 9584 - 9590

PubMed ID

  • 19553307

Pubmed Central ID

  • 19553307

Electronic International Standard Serial Number (EISSN)

  • 1098-5514

Digital Object Identifier (DOI)

  • 10.1128/JVI.00821-09

Language

  • eng

Conference Location

  • United States