Dynamic immune responses maintain cytotoxic T lymphocyte epitope mutations in transmitted simian immunodeficiency virus variants.

Published

Journal Article

Viral escape from cytotoxic T lymphocytes (CTLs) can undermine immune control of human immunodeficiency virus 1. It is therefore important to assess the stability of viral mutations in CTL epitopes after transmission to naive hosts. Here we demonstrate the persistence of mutations in a dominant CTL epitope after transmission of simian immunodeficiency virus variants to major histocompatibility complex-matched rhesus monkeys. Transient reversions to wild-type sequences occurred and elicited CTLs specific for the wild-type epitope, resulting in immunological pressure that rapidly reselected the mutant viruses. These data suggest that mutations in dominant human immunodeficiency virus 1 CTL epitopes may accumulate in human populations with limited major histocompatibility complex heterogeneity by a mechanism involving dynamic CTL control of transiently reverted wild-type virus.

Full Text

Duke Authors

Cited Authors

  • Barouch, DH; Powers, J; Truitt, DM; Kishko, MG; Arthur, JC; Peyerl, FW; Kuroda, MJ; Gorgone, DA; Lifton, MA; Lord, CI; Hirsch, VM; Montefiori, DC; Carville, A; Mansfield, KG; Kunstman, KJ; Wolinsky, SM; Letvin, NL

Published Date

  • March 2005

Published In

Volume / Issue

  • 6 / 3

Start / End Page

  • 247 - 252

PubMed ID

  • 15685174

Pubmed Central ID

  • 15685174

International Standard Serial Number (ISSN)

  • 1529-2908

Digital Object Identifier (DOI)

  • 10.1038/ni1167

Language

  • eng

Conference Location

  • United States