Aiming to induce broadly reactive neutralizing antibody responses with HIV-1 vaccine candidates.
Journal Article (Journal Article;Review)
Neutralizing antibody induction is a key feature of many effective vaccines and is the only immune response that has proven to be capable of completely blocking AIDS virus infection in animal models. Unfortunately, the extensive genetic variability and complex immune-evasion strategies of HIV-1 have thwarted all attempts to date at eliciting an effective neutralizing antibody response with candidate HIV-1 vaccine immunogens. Recent advances in our understanding of how these evasion strategies operate, coupled with growing progress in unravelling the structure and immunobiology of the viral envelope glycoproteins, are contributing to novel immunogen designs to overcome the many barriers to inducing protective antibodies against HIV-1.
Full Text
Duke Authors
Cited Authors
- Haynes, BF; Montefiori, DC
Published Date
- June 2006
Published In
Volume / Issue
- 5 / 3
Start / End Page
- 347 - 363
PubMed ID
- 16827619
Pubmed Central ID
- PMC2716009
Electronic International Standard Serial Number (EISSN)
- 1744-8395
Digital Object Identifier (DOI)
- 10.1586/14760584.5.3.347
Language
- eng
Conference Location
- England