Early development of near-infrared spectroscopy at Duke University.

Journal Article (Journal Article)

Optical monitoring of living tissues in the near-infrared (NIR) region of the spectrum (700 to 1300 nm) was first demonstrated some 30 years ago by Professor Frans F. Jobsis of Duke University. Jobsis had intended to study the oxidation-reduction (redox) behavior of the copper band (CuA) of cytochrome c oxidase (cyt a,a(3)) to understand certain anomalies in the behavior of the mitochondrial respiratory chain in the ultraviolet and visible regions between living tissue and isolated preparations of mitochondria. Instead, he discovered a new window into the body-for NIR light penetrates deeply into living tissues. Jobsis's pioneering studies proved it was possible to interrogate hemoglobin absorption and saturation and to assess the redox state of vital organs such as the brain directly through skin and bone. He and his collaborators had also recognized that the tissue hemoglobin signals provided valuable information about the oxygen (O(2)) content of the tissue, and cyt a,a(3) signaled the availability of cellular O(2) for oxidative phosphorylation. The ability to noninvasively monitor the O(2) delivery-uptake relationship has made NIR spectroscopy a unique tool for the assessment of tissue oxygen sufficiency in health and disease.

Full Text

Duke Authors

Cited Authors

  • Piantadosi, CA

Published Date

  • 2007

Published In

Volume / Issue

  • 12 / 6

Start / End Page

  • 062102 -

PubMed ID

  • 18163805

International Standard Serial Number (ISSN)

  • 1083-3668

Digital Object Identifier (DOI)

  • 10.1117/1.2804925


  • eng

Conference Location

  • United States