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Two faces of nitric oxide: implications for cellular mechanisms of oxygen toxicity.

Publication ,  Journal Article
Allen, BW; Demchenko, IT; Piantadosi, CA
Published in: J Appl Physiol (1985)
February 2009

Recent investigations have elucidated some of the diverse roles played by reactive oxygen and nitrogen species in events that lead to oxygen toxicity and defend against it. The focus of this review is on toxic and protective mechanisms in hyperoxia that have been investigated in our laboratories, with an emphasis on interactions of nitric oxide (NO) with other endogenous chemical species and with different physiological systems. It is now emerging from these studies that the anatomical localization of NO release, which depends, in part, on whether the oxygen exposure is normobaric or hyperbaric, strongly influences whether toxicity emerges and what form it takes, for example, acute lung injury, central nervous system excitation, or both. Spatial effects also contribute to differences in the susceptibility of different cells in organs at risk from hyperoxia, especially in the brain and lungs. As additional nodes are identified in this interactive network of toxic and protective responses, future advances may open up the possibility of novel pharmacological interventions to extend both the time and partial pressures of oxygen exposures that can be safely tolerated. The implications of a better understanding of the mechanisms by which NO contributes to central nervous system oxygen toxicity may include new insights into the pathogenesis of seizures of diverse etiologies. Likewise, improved knowledge of NO-based mechanisms of pulmonary oxygen toxicity may enhance our understanding of other types of lung injury associated with oxidative or nitrosative stress.

Duke Scholars

Published In

J Appl Physiol (1985)

DOI

ISSN

8750-7587

Publication Date

February 2009

Volume

106

Issue

2

Start / End Page

662 / 667

Location

United States

Related Subject Headings

  • Superoxide Dismutase
  • Reactive Oxygen Species
  • Physiology
  • Peroxynitrous Acid
  • Oxygen
  • Oxidative Stress
  • Nitric Oxide Synthase Type I
  • Nitric Oxide
  • Hyperoxia
  • Hyperbaric Oxygenation
 

Citation

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Allen, B. W., Demchenko, I. T., & Piantadosi, C. A. (2009). Two faces of nitric oxide: implications for cellular mechanisms of oxygen toxicity. J Appl Physiol (1985), 106(2), 662–667. https://doi.org/10.1152/japplphysiol.91109.2008
Allen, Barry W., Ivan T. Demchenko, and Claude A. Piantadosi. “Two faces of nitric oxide: implications for cellular mechanisms of oxygen toxicity.J Appl Physiol (1985) 106, no. 2 (February 2009): 662–67. https://doi.org/10.1152/japplphysiol.91109.2008.
Allen BW, Demchenko IT, Piantadosi CA. Two faces of nitric oxide: implications for cellular mechanisms of oxygen toxicity. J Appl Physiol (1985). 2009 Feb;106(2):662–7.
Allen, Barry W., et al. “Two faces of nitric oxide: implications for cellular mechanisms of oxygen toxicity.J Appl Physiol (1985), vol. 106, no. 2, Feb. 2009, pp. 662–67. Pubmed, doi:10.1152/japplphysiol.91109.2008.
Allen BW, Demchenko IT, Piantadosi CA. Two faces of nitric oxide: implications for cellular mechanisms of oxygen toxicity. J Appl Physiol (1985). 2009 Feb;106(2):662–667.

Published In

J Appl Physiol (1985)

DOI

ISSN

8750-7587

Publication Date

February 2009

Volume

106

Issue

2

Start / End Page

662 / 667

Location

United States

Related Subject Headings

  • Superoxide Dismutase
  • Reactive Oxygen Species
  • Physiology
  • Peroxynitrous Acid
  • Oxygen
  • Oxidative Stress
  • Nitric Oxide Synthase Type I
  • Nitric Oxide
  • Hyperoxia
  • Hyperbaric Oxygenation