Skip to main content
Journal cover image

Interleukin-15 increases hepatic regenerative activity.

Publication ,  Journal Article
Suzuki, A; McCall, S; Choi, SS; Sicklick, JK; Huang, J; Qi, Y; Zdanowicz, M; Camp, T; Li, Y-X; Diehl, AM
Published in: J Hepatol
September 2006

BACKGROUND/AIMS: Interleukin-15 (IL-15) is expressed in many organs. It generally inhibits apoptosis and increases cellular proliferation and differentiation. However, IL-15's roles in liver are unknown. We aimed to determine if IL-15 influences hepatic integrity and regenerative activity. METHODS: Expression of IL-15 and its receptors was evaluated in several liver injury models, primary hepatocytes, and two liver cell lines. Effects of IL-15 on viability, proliferation, and apoptosis were assessed in cultured liver cells, and also in the livers of healthy mice. RESULTS: IL-15 and its receptors are expressed constitutively in healthy livers, and ligand expression is induced in injured livers. Cultured primary hepatocytes and liver cell lines express IL-15 and its receptors. Administration of IL-15 has minimal effects on cultured liver cells, but significantly up-regulates oval cell accumulation, cyclin mRNA expression, and mature hepatocyte replication in healthy mice. These effects are associated with focal hepatic inflammation and increased expression of TNF-alpha and IFN-gamma, but not with increased cell death or aminotransferase release. CONCLUSIONS: IL-15 expression increases during liver injury and IL-15 treatment induces a wound healing-type response in healthy adult mice. These findings suggest that IL-15 may contribute to regenerative activity in damaged liver.

Duke Scholars

Published In

J Hepatol

DOI

ISSN

0168-8278

Publication Date

September 2006

Volume

45

Issue

3

Start / End Page

410 / 418

Location

Netherlands

Related Subject Headings

  • Wound Healing
  • Tumor Necrosis Factor-alpha
  • Receptors, Interleukin-15
  • RNA, Messenger
  • Mice, Obese
  • Mice, Inbred C57BL
  • Mice
  • Male
  • Liver Regeneration
  • Liver
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Suzuki, A., McCall, S., Choi, S. S., Sicklick, J. K., Huang, J., Qi, Y., … Diehl, A. M. (2006). Interleukin-15 increases hepatic regenerative activity. J Hepatol, 45(3), 410–418. https://doi.org/10.1016/j.jhep.2006.04.008
Suzuki, Ayako, Shannon McCall, Steve S. Choi, Jason K. Sicklick, Jiawen Huang, Yi Qi, Marzena Zdanowicz, Terese Camp, Yin-Xiong Li, and Anna Mae Diehl. “Interleukin-15 increases hepatic regenerative activity.J Hepatol 45, no. 3 (September 2006): 410–18. https://doi.org/10.1016/j.jhep.2006.04.008.
Suzuki A, McCall S, Choi SS, Sicklick JK, Huang J, Qi Y, et al. Interleukin-15 increases hepatic regenerative activity. J Hepatol. 2006 Sep;45(3):410–8.
Suzuki, Ayako, et al. “Interleukin-15 increases hepatic regenerative activity.J Hepatol, vol. 45, no. 3, Sept. 2006, pp. 410–18. Pubmed, doi:10.1016/j.jhep.2006.04.008.
Suzuki A, McCall S, Choi SS, Sicklick JK, Huang J, Qi Y, Zdanowicz M, Camp T, Li Y-X, Diehl AM. Interleukin-15 increases hepatic regenerative activity. J Hepatol. 2006 Sep;45(3):410–418.
Journal cover image

Published In

J Hepatol

DOI

ISSN

0168-8278

Publication Date

September 2006

Volume

45

Issue

3

Start / End Page

410 / 418

Location

Netherlands

Related Subject Headings

  • Wound Healing
  • Tumor Necrosis Factor-alpha
  • Receptors, Interleukin-15
  • RNA, Messenger
  • Mice, Obese
  • Mice, Inbred C57BL
  • Mice
  • Male
  • Liver Regeneration
  • Liver