Hedgehog signaling in the liver.

Journal Article (Journal Article;Review)

Reactivation of Hedgehog (Hh), a morphogenic signaling pathway that controls progenitor cell fate and tissue construction during embryogenesis occurs during many types of liver injury in adult. The net effects of activating the Hedgehog pathway include expansion of liver progenitor populations to promote liver regeneration, but also hepatic accumulation of inflammatory cells, liver fibrogenesis, and vascular remodeling. All of these latter responses are known to be involved in the pathogenesis of cirrhosis. In addition, Hh signaling may play a role in primary liver cancers, such as cholangiocarcinoma and hepatocellular carcinoma. Study of Hedgehog signaling in liver cells is in its infancy. Additional research in this area is justified given growing experimental and clinical data supporting a role for the pathway in regulating outcomes of liver injury.

Full Text

Duke Authors

Cited Authors

  • Omenetti, A; Choi, S; Michelotti, G; Diehl, AM

Published Date

  • February 2011

Published In

Volume / Issue

  • 54 / 2

Start / End Page

  • 366 - 373

PubMed ID

  • 21093090

Pubmed Central ID

  • PMC3053023

Electronic International Standard Serial Number (EISSN)

  • 1600-0641

Digital Object Identifier (DOI)

  • 10.1016/j.jhep.2010.10.003


  • eng

Conference Location

  • Netherlands