Performance of the AST-to-platelet ratio index as a noninvasive marker of fibrosis in pediatric patients with chronic viral hepatitis.

Journal Article (Journal Article)

We investigated the performance of aspartate aminotransferase to platelet ratio index (APRI) as a noninvasive marker of fibrosis and cirrhosis in children with chronic viral hepatitis. All of the patients 0 to 20 years old with chronic hepatitis B or C presenting at a tertiary medical center from 1992 to 2008 were identified. Thirty-six patients were evaluated with 48 biopsy results. The areas under the receiver operating characteristic curve were 0.71 for fibrosis and 0.52 for cirrhosis. When examining subgroups, the APRI performed better in older patients and in those with vertically transmitted hepatitis C virus. Further research into APRI and the other noninvasive markers of fibrosis in children with chronic viral hepatitis is warranted.

Full Text

Duke Authors

Cited Authors

  • McGoogan, KE; Smith, PB; Choi, SS; Berman, W; Jhaveri, R

Published Date

  • March 2010

Published In

Volume / Issue

  • 50 / 3

Start / End Page

  • 344 - 346

PubMed ID

  • 20118806

Pubmed Central ID

  • PMC3314885

Electronic International Standard Serial Number (EISSN)

  • 1536-4801

Digital Object Identifier (DOI)

  • 10.1097/MPG.0b013e3181aed725


  • eng

Conference Location

  • United States