Apoptosis and cytokines in non-alcoholic steatohepatitis.

Journal Article (Journal Article)

Non-alcoholic fatty liver disease (NAFLD), one of the commonest causes of chronic liver disease in the United States, represents several overlapping clinicopathological states, ranging from simple steatosis to non-alcoholic steatohepatitis (NASH). Although dysregulated lipid accumulation occurs across the spectrum of NAFLD, features of liver cell injury, such as hepatocyte ballooning, cytoskeletal changes (Mallory-Denk bodies), and hepatocyte apoptosis, occur predominantly in NASH and distinguish NASH from simple steatosis. Indeed, NASH is a more serious form of liver damage because cirrhosis and hepatocellular carcinoma are potential outcomes of NASH. Meanwhile, cirrhosis and hepatocellular carcinoma rarely occur in individuals with simple steatosis. Hepatic injury and apoptosis that occur in adults are often dysregulated and accompanied by the accumulation of immune cells, which produce cytokines and growth factors that drive chronic inflammation and may result in fibrosis. This article summarizes the process of apoptosis and roles of putative cytokines in progressive NAFLD.

Full Text

Duke Authors

Cited Authors

  • Syn, W-K; Choi, SS; Diehl, AM

Published Date

  • November 2009

Published In

Volume / Issue

  • 13 / 4

Start / End Page

  • 565 - 580

PubMed ID

  • 19818305

Pubmed Central ID

  • PMC2766093

Electronic International Standard Serial Number (EISSN)

  • 1557-8224

Digital Object Identifier (DOI)

  • 10.1016/j.cld.2009.07.003


  • eng

Conference Location

  • United States