The role of Hedgehog signaling in fibrogenic liver repair.

Journal Article (Journal Article;Review)

Repair of adult liver, like many tissues, involves the coordinated response of a number of different cell types. In adult livers, fibroblastic cells, ductular cells, inflammatory cells, and progenitor cells contribute to this process. Our studies demonstrate that the fates of such cells are dictated, at least in part, by Hedgehog, a fetal morphogenic pathway that was once thought to be active mainly during embryogenesis. Studies of injured adult human and rodent livers demonstrate that injury-related activation of the Hedgehog pathway modulates several important aspects of repair, including the growth of hepatic progenitor populations, hepatic accumulation of myofibroblasts, repair-related inflammatory responses, vascular remodeling, liver fibrosis and hepatocarcinogenesis. These findings identify the Hedgehog pathway as a potentially important target for biomarker development and therapeutic manipulation, and emphasize the need for further research to advance knowledge about how this pathway is regulated by and interacts with other signals that regulate adult liver repair.

Full Text

Duke Authors

Cited Authors

  • Choi, SS; Omenetti, A; Syn, W-K; Diehl, AM

Published Date

  • February 2011

Published In

Volume / Issue

  • 43 / 2

Start / End Page

  • 238 - 244

PubMed ID

  • 21056686

Pubmed Central ID

  • PMC3022074

Electronic International Standard Serial Number (EISSN)

  • 1878-5875

Digital Object Identifier (DOI)

  • 10.1016/j.biocel.2010.10.015


  • eng

Conference Location

  • Netherlands