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Effect of gadolinium chelate contrast agents on diffusion weighted MR imaging of the liver, spleen, pancreas and kidney at 3 T.

Publication ,  Journal Article
Wang, CL; Chea, YW; Boll, DT; Samei, E; Neville, AM; Dale, BM; Merkle, EM
Published in: Eur J Radiol
November 2011

PURPOSE: To retrospectively test the null hypotheses that the qualitative appearance of DWI and the signal intensity values in DWI and corresponding ADC values of the liver, spleen, pancreas and kidneys are identical before and after the administration of gadolinium. MATERIALS AND METHODS: Following IRB approval, DWI was acquired in 50 patients (25 male; mean age 54.9 years) prior to and after contrast administration, using single-shot echo planar imaging with b-values of 50 s/mm2 and 800 s/mm2 at 3 T. Binomial analysis was used to determine which image set was more significantly preferred in conveying the diffusion information. Pre- and post-gadolinium DWI and ADC values of corresponding regions of each organ were analyzed using standardized signal intensity measurements. RESULTS: Pre-contrast DWI images of the liver, spleen, and pancreas were preferred 52%, 49%, and 58%, respectively, with none of the differences being statistically significant. DWI of the kidneys was preferred on pre-contrast images in 83% (p<0.001). In the liver and spleen, contrast caused a significant increase in the post-contrast DWI signal intensity values at b=50 (p<0.02) and b=800 (p<0.05) but had no statistically significant effect on the ADC value (p>0.40). Pancreatic DWI signal intensity and ADC values pre- and post-contrast were also not significantly different (p=0.489). In the renal parenchyma, significant decrease in the values of DWI at b=50 (p<0.01) and b=800 (p<0.01) as well as ADC (p<0.02) was demonstrated following gadolinium administration. CONCLUSION: Intravenous gadolinium administration does not make a statistically significant difference in the qualitative appearance or ADC measurements of the liver, spleen, or pancreas when comparing pre-contrast to post-contrast DWI. In the kidneys, however, ADC values are significantly lower post-contrast with the pre-contrast diffusion weighted images also being qualitatively preferred.

Duke Scholars

Published In

Eur J Radiol

DOI

EISSN

1872-7727

Publication Date

November 2011

Volume

80

Issue

2

Start / End Page

e1 / e7

Location

Ireland

Related Subject Headings

  • Splenic Diseases
  • Retrospective Studies
  • Pancreatic Diseases
  • Organometallic Compounds
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Meglumine
  • Male
  • Liver Diseases
  • Kidney Diseases
 

Citation

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Wang, C. L., Chea, Y. W., Boll, D. T., Samei, E., Neville, A. M., Dale, B. M., & Merkle, E. M. (2011). Effect of gadolinium chelate contrast agents on diffusion weighted MR imaging of the liver, spleen, pancreas and kidney at 3 T. Eur J Radiol, 80(2), e1–e7. https://doi.org/10.1016/j.ejrad.2010.05.019
Wang, Carolyn Lee, Yen Wei Chea, Daniel T. Boll, Ehsan Samei, Amy M. Neville, Brian M. Dale, and Elmar M. Merkle. “Effect of gadolinium chelate contrast agents on diffusion weighted MR imaging of the liver, spleen, pancreas and kidney at 3 T.Eur J Radiol 80, no. 2 (November 2011): e1–7. https://doi.org/10.1016/j.ejrad.2010.05.019.
Wang CL, Chea YW, Boll DT, Samei E, Neville AM, Dale BM, et al. Effect of gadolinium chelate contrast agents on diffusion weighted MR imaging of the liver, spleen, pancreas and kidney at 3 T. Eur J Radiol. 2011 Nov;80(2):e1–7.
Wang, Carolyn Lee, et al. “Effect of gadolinium chelate contrast agents on diffusion weighted MR imaging of the liver, spleen, pancreas and kidney at 3 T.Eur J Radiol, vol. 80, no. 2, Nov. 2011, pp. e1–7. Pubmed, doi:10.1016/j.ejrad.2010.05.019.
Wang CL, Chea YW, Boll DT, Samei E, Neville AM, Dale BM, Merkle EM. Effect of gadolinium chelate contrast agents on diffusion weighted MR imaging of the liver, spleen, pancreas and kidney at 3 T. Eur J Radiol. 2011 Nov;80(2):e1–e7.
Journal cover image

Published In

Eur J Radiol

DOI

EISSN

1872-7727

Publication Date

November 2011

Volume

80

Issue

2

Start / End Page

e1 / e7

Location

Ireland

Related Subject Headings

  • Splenic Diseases
  • Retrospective Studies
  • Pancreatic Diseases
  • Organometallic Compounds
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Meglumine
  • Male
  • Liver Diseases
  • Kidney Diseases