Relationship between exposure, clinical malaria, and age in an area of changing transmission intensity.

Published

Journal Article

The relationship between malaria transmission intensity and clinical disease is important for predicting the outcome of control measures that reduce transmission. Comparisons of hospital data between areas of differing transmission intensity suggest that the mean age of hospitalized clinical malaria is higher under relatively lower transmission, but the total number of episodes is similar until transmission drops below a threshold, where the risks of hospitalized malaria decline. These observations have rarely been examined longitudinally in a single community where transmission declines over time. We reconstructed 16 years (1991-2006) of pediatric hospital surveillance data and infection prevalence surveys from a circumscribed geographic area on the Kenyan coast. The incidence of clinical malaria remained high, despite sustained reductions in exposure to infection. However, the age group experiencing the clinical attacks of malaria increased steadily as exposure declined and may precede changes in the number of episodes in an area with declining transmission.

Full Text

Duke Authors

Cited Authors

  • O'Meara, WP; Mwangi, TW; Williams, TN; McKenzie, FE; Snow, RW; Marsh, K

Published Date

  • August 2008

Published In

Volume / Issue

  • 79 / 2

Start / End Page

  • 185 - 191

PubMed ID

  • 18689622

Pubmed Central ID

  • 18689622

Electronic International Standard Serial Number (EISSN)

  • 1476-1645

International Standard Serial Number (ISSN)

  • 0002-9637

Digital Object Identifier (DOI)

  • 10.4269/ajtmh.2008.79.185

Language

  • eng