Malaria vaccine efficacy: the difficulty of detecting and diagnosing malaria.

Journal Article (Journal Article;Review)

New sources of funding have revitalized efforts to control malaria. An effective vaccine would be a tremendous asset in the fight against this devastating disease and increasing financial and scientific resources are being invested to develop one. A few candidates have been tested in Phase I and II clinical trials, and several others are poised to begin trials soon. Some studies have been promising, and others disappointing. It is difficult to compare the results of these clinical trials; even independent trials of the same vaccine give highly discrepant results. One major obstacle in evaluating malaria vaccines is the difficulty of diagnosing clinical malaria. This analysis evaluates the impact of diagnostic error, particularly that introduced by microscopy, on the outcome of efficacy trials of malaria vaccines and make recommendations for improving future trials.

Full Text

Duke Authors

Cited Authors

  • O'Meara, WP; Hall, BF; McKenzie, FE

Published Date

  • March 26, 2007

Published In

Volume / Issue

  • 6 /

Start / End Page

  • 36 -

PubMed ID

  • 17386083

Pubmed Central ID

  • PMC1852320

Electronic International Standard Serial Number (EISSN)

  • 1475-2875

Digital Object Identifier (DOI)

  • 10.1186/1475-2875-6-36


  • eng

Conference Location

  • England