Malaria vaccine efficacy: the difficulty of detecting and diagnosing malaria.
Published online
Journal Article (Review)
New sources of funding have revitalized efforts to control malaria. An effective vaccine would be a tremendous asset in the fight against this devastating disease and increasing financial and scientific resources are being invested to develop one. A few candidates have been tested in Phase I and II clinical trials, and several others are poised to begin trials soon. Some studies have been promising, and others disappointing. It is difficult to compare the results of these clinical trials; even independent trials of the same vaccine give highly discrepant results. One major obstacle in evaluating malaria vaccines is the difficulty of diagnosing clinical malaria. This analysis evaluates the impact of diagnostic error, particularly that introduced by microscopy, on the outcome of efficacy trials of malaria vaccines and make recommendations for improving future trials.
Full Text
Duke Authors
Cited Authors
- O'Meara, WP; Hall, BF; McKenzie, FE
Published Date
- March 26, 2007
Published In
Volume / Issue
- 6 /
Start / End Page
- 36 -
PubMed ID
- 17386083
Pubmed Central ID
- 17386083
Electronic International Standard Serial Number (EISSN)
- 1475-2875
Digital Object Identifier (DOI)
- 10.1186/1475-2875-6-36
Language
- eng
Conference Location
- England