Fever in patients with mixed-species malaria.


Journal Article

BACKGROUND: Clinical symptoms of mixed-species malaria infections have been variously reported as both less severe and more severe than those of single-species infections. METHODS: Oral temperatures were taken from and blood slides were prepared for 2308 adults who presented at outpatient malaria clinics in Tak Province (Thailand) during May-August 1998, May-July 1999, and May-June 2001 with malaria infections diagnosed by 2 expert research microscopists, each of whom was blinded to the other's reports. RESULTS: In each year, temperatures of patients with mixed Plasmodium vivax-Plasmodium falciparum infections were higher than temperatures of patients with P. vivax or P. falciparum infections. In every mixed-species case, P. falciparum parasitemia was higher than P. vivax parasitemia, but patient temperature was not correlated with the parasitemia of either species or with the total parasitemia. CONCLUSIONS: Among adults who self-report to malaria clinics in western Thailand, patients with mixed P. vivax-P. falciparum infections have higher fevers than patients with single-species infections, a distinction that cannot be attributed to differences in parasitemia. This observation warrants more detailed investigations, spanning wider ranges of ages and transmission environments.

Full Text

Duke Authors

Cited Authors

  • McKenzie, FE; Smith, DL; O'Meara, WP; Forney, JR; Magill, AJ; Permpanich, B; Erhart, LM; Sirichaisinthop, J; Wongsrichanalai, C; Gasser, RA

Published Date

  • June 15, 2006

Published In

Volume / Issue

  • 42 / 12

Start / End Page

  • 1713 - 1718

PubMed ID

  • 16705577

Pubmed Central ID

  • 16705577

Electronic International Standard Serial Number (EISSN)

  • 1537-6591

Digital Object Identifier (DOI)

  • 10.1086/504330


  • eng

Conference Location

  • United States