Fragility and mechanosensing in a thermalized cytoskeleton model with forced protein unfolding.
Publication
, Journal Article
Hoffman, BD; Massiera, G; Crocker, JC
Published in: Physical review. E, Statistical, nonlinear, and soft matter physics
November 2007
We describe a model of cytoskeletal mechanics based on the force-induced conformational change of protein cross-links in a stressed polymer network. Slow deformation of simulated networks containing cross-links that undergo repeated, serial domain unfolding leads to an unusual state-with many cross-links accumulating near the critical force for further unfolding. This state is robust to thermalization and does not occur in similar protein unbinding based simulations. Moreover, we note that the unusual configuration of near-critical protein cross-links in the fragile state provides a physical mechanism for the chemical transduction of cell-level mechanical strain and extra-cellular matrix stiffness.
Duke Scholars
Published In
Physical review. E, Statistical, nonlinear, and soft matter physics
DOI
EISSN
1550-2376
ISSN
1539-3755
Publication Date
November 2007
Volume
76
Issue
5 Pt 1
Start / End Page
051906
Related Subject Headings
- Stress, Mechanical
- Protein Folding
- Motion
- Models, Molecular
- Models, Chemical
- Models, Biological
- Mechanotransduction, Cellular
- Fluids & Plasmas
- Elasticity
- Cytoskeleton
Citation
APA
Chicago
ICMJE
MLA
NLM
Hoffman, B. D., Massiera, G., & Crocker, J. C. (2007). Fragility and mechanosensing in a thermalized cytoskeleton model with forced protein unfolding. Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics, 76(5 Pt 1), 051906. https://doi.org/10.1103/physreve.76.051906
Hoffman, Brenton D., Gladys Massiera, and John C. Crocker. “Fragility and mechanosensing in a thermalized cytoskeleton model with forced protein unfolding.” Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics 76, no. 5 Pt 1 (November 2007): 051906. https://doi.org/10.1103/physreve.76.051906.
Hoffman BD, Massiera G, Crocker JC. Fragility and mechanosensing in a thermalized cytoskeleton model with forced protein unfolding. Physical review E, Statistical, nonlinear, and soft matter physics. 2007 Nov;76(5 Pt 1):051906.
Hoffman, Brenton D., et al. “Fragility and mechanosensing in a thermalized cytoskeleton model with forced protein unfolding.” Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics, vol. 76, no. 5 Pt 1, Nov. 2007, p. 051906. Epmc, doi:10.1103/physreve.76.051906.
Hoffman BD, Massiera G, Crocker JC. Fragility and mechanosensing in a thermalized cytoskeleton model with forced protein unfolding. Physical review E, Statistical, nonlinear, and soft matter physics. 2007 Nov;76(5 Pt 1):051906.
Published In
Physical review. E, Statistical, nonlinear, and soft matter physics
DOI
EISSN
1550-2376
ISSN
1539-3755
Publication Date
November 2007
Volume
76
Issue
5 Pt 1
Start / End Page
051906
Related Subject Headings
- Stress, Mechanical
- Protein Folding
- Motion
- Models, Molecular
- Models, Chemical
- Models, Biological
- Mechanotransduction, Cellular
- Fluids & Plasmas
- Elasticity
- Cytoskeleton