Evolving standards in the treatment of docetaxel-refractory castration-resistant prostate cancer.
Published
Journal Article (Review)
The management of men with metastatic castration-resistant prostate cancer (CRPC) has taken several leaps forward in the past year, with the demonstration of improved overall survival with three novel agents (sipuleucel-T, cabazitaxel with prednisone and abiraterone acetate with prednisone), and a significant delay in skeletal-related events observed with denosumab. The pipeline of systemic therapies in prostate cancer remains strong, as multiple agents with a diverse array of mechanisms of action are showing preliminary signs of clinical benefit, leading to more definitive phase III confirmatory trials. In this review, which represents part 1 of a two-part series on metastatic CRPC, we will summarize the mechanisms of resistance to hormonal and chemotherapies and discuss the evolving landscape of treatment options for men with CRPC, with a particular focus on currently approved and emerging treatment options following docetaxel administration, as well as prognostic factors in this post-docetaxel state. As docetaxel remains the standard initial systemic therapy for men with metastatic CRPC for both palliative and life-prolonging purposes, knowledge of these evolving standards will help to optimize delivery of care and long-term outcomes.
Full Text
Duke Authors
Cited Authors
- Antonarakis, ES; Armstrong, AJ
Published Date
- September 2011
Published In
Volume / Issue
- 14 / 3
Start / End Page
- 192 - 205
PubMed ID
- 21577234
Pubmed Central ID
- 21577234
Electronic International Standard Serial Number (EISSN)
- 1476-5608
Digital Object Identifier (DOI)
- 10.1038/pcan.2011.23
Language
- eng
Conference Location
- England