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New drug development in metastatic prostate cancer.

Publication ,  Journal Article
Armstrong, AJ; George, DJ
Published in: Urol Oncol
2008

In 2007, drug development in castration-resistant metastatic prostate cancer (CRPC) remains challenging, due to the number of potentially viable molecular targets and clinical trials available, the lack of established surrogates for overall survival, and competing causes of mortality. This review will highlight the highest impact phase II and phase III trials of novel agents in the current CRPC landscape, and focus on both molecular targets and clinical trial designs that are more likely to demonstrate clinical benefit. The need for tissue correlative studies for target evaluation and drug mechanism is stressed to continue to advance the field and to define biomarkers that may identify patient populations that may derive a greater benefit from these molecular agents.

Duke Scholars

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Published In

Urol Oncol

DOI

ISSN

1078-1439

Publication Date

2008

Volume

26

Issue

4

Start / End Page

430 / 437

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Prostatic Neoplasms
  • Orchiectomy
  • Neoplasm Metastasis
  • Male
  • Immunotherapy
  • Humans
  • Drug Design
  • Cell Survival
  • Cell Proliferation
 

Citation

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ICMJE
MLA
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Armstrong, A. J., & George, D. J. (2008). New drug development in metastatic prostate cancer. Urol Oncol, 26(4), 430–437. https://doi.org/10.1016/j.urolonc.2007.11.006
Armstrong, Andrew J., and Daniel J. George. “New drug development in metastatic prostate cancer.Urol Oncol 26, no. 4 (2008): 430–37. https://doi.org/10.1016/j.urolonc.2007.11.006.
Armstrong AJ, George DJ. New drug development in metastatic prostate cancer. Urol Oncol. 2008;26(4):430–7.
Armstrong, Andrew J., and Daniel J. George. “New drug development in metastatic prostate cancer.Urol Oncol, vol. 26, no. 4, 2008, pp. 430–37. Pubmed, doi:10.1016/j.urolonc.2007.11.006.
Armstrong AJ, George DJ. New drug development in metastatic prostate cancer. Urol Oncol. 2008;26(4):430–437.
Journal cover image

Published In

Urol Oncol

DOI

ISSN

1078-1439

Publication Date

2008

Volume

26

Issue

4

Start / End Page

430 / 437

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Prostatic Neoplasms
  • Orchiectomy
  • Neoplasm Metastasis
  • Male
  • Immunotherapy
  • Humans
  • Drug Design
  • Cell Survival
  • Cell Proliferation