History of cancer in first degree relatives of Barrett's esophagus patients: a case-control study.


Journal Article

BACKGROUND AND OBJECTIVE: Familial clusters of Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) have been reported. This study evaluates the history of cancer in BE patients families. METHODS: In two years, patients with BE (272), esophagitis (456) and controls (517) were recruited in 12 Italian Endoscopy Units. Cancer family history in first-degree (FD) relatives was determined by a questionnaire. RESULTS: Approximately 53% of BE, 51% of esophagitis, and 48% of controls had at least one relative affected by any type of malignancy. Probands with at least one esophageal or gastric (E/G) cancer-affected relative showed a BE risk which was at least eighty-five percent higher than that of probands without affected relatives. The relative risk of BE was 4.18, 95% CL=0.76-23.04 if a FD relative had early (mean age ≤ 50 years) onset E/G cancer compared to late onset E/G cancer. CONCLUSION: In this sample there was no evidence that a family history of cancer was associated with the diagnosis of BE. An intriguing result was the association between the occurrence of E/G cancers at earlier ages (< 50 years) among BE relatives with respect the control group. This could suggest a genetic contribution in onset of these tumors, but the sample was too small to demonstrate a significant association. Further exploration of family history of E/G cancer and a diagnosis of BE in larger samples is warranted.

Full Text

Duke Authors

Cited Authors

  • De Ceglie, A; Filiberti, R; Blanchi, S; Fontana, V; Fisher, DA; Grossi, E; Lacchin, T; De Matthaeis, M; Ignomirelli, O; Cappiello, R; Casa, DD; Foti, M; Laterza, F; Rosati, R; Annese, V; Iaquinto, G; Conio, M

Published Date

  • December 2011

Published In

Volume / Issue

  • 35 / 12

Start / End Page

  • 831 - 838

PubMed ID

  • 21924696

Pubmed Central ID

  • 21924696

Electronic International Standard Serial Number (EISSN)

  • 2210-741X

Digital Object Identifier (DOI)

  • 10.1016/j.clinre.2011.07.015


  • eng

Conference Location

  • France