The genome of the sea urchin Strongylocentrotus purpuratus.

Published

Journal Article

We report the sequence and analysis of the 814-megabase genome of the sea urchin Strongylocentrotus purpuratus, a model for developmental and systems biology. The sequencing strategy combined whole-genome shotgun and bacterial artificial chromosome (BAC) sequences. This use of BAC clones, aided by a pooling strategy, overcame difficulties associated with high heterozygosity of the genome. The genome encodes about 23,300 genes, including many previously thought to be vertebrate innovations or known only outside the deuterostomes. This echinoderm genome provides an evolutionary outgroup for the chordates and yields insights into the evolution of deuterostomes.

Full Text

Duke Authors

Cited Authors

  • Sea Urchin Genome Sequencing Consortium, ; Sodergren, E; Weinstock, GM; Davidson, EH; Cameron, RA; Gibbs, RA; Angerer, RC; Angerer, LM; Arnone, MI; Burgess, DR; Burke, RD; Coffman, JA; Dean, M; Elphick, MR; Ettensohn, CA; Foltz, KR; Hamdoun, A; Hynes, RO; Klein, WH; Marzluff, W; McClay, DR; Morris, RL; Mushegian, A; Rast, JP; Smith, LC; Thorndyke, MC; Vacquier, VD; Wessel, GM; Wray, G; Zhang, L; Elsik, CG; Ermolaeva, O; Hlavina, W; Hofmann, G; Kitts, P; Landrum, MJ; Mackey, AJ; Maglott, D; Panopoulou, G; Poustka, AJ; Pruitt, K; Sapojnikov, V; Song, X; Souvorov, A; Solovyev, V; Wei, Z; Whittaker, CA; Worley, K; Durbin, KJ; Shen, Y; Fedrigo, O; Garfield, D; Haygood, R; Primus, A; Satija, R; Severson, T; Gonzalez-Garay, ML; Jackson, AR; Milosavljevic, A; Tong, M; Killian, CE; Livingston, BT; Wilt, FH; Adams, N; Bellé, R; Carbonneau, S; Cheung, R; Cormier, P; Cosson, B; Croce, J; Fernandez-Guerra, A; Genevière, A-M; Goel, M; Kelkar, H; Morales, J; Mulner-Lorillon, O; Robertson, AJ; Goldstone, JV; Cole, B; Epel, D; Gold, B; Hahn, ME; Howard-Ashby, M; Scally, M; Stegeman, JJ; Allgood, EL; Cool, J; Judkins, KM; McCafferty, SS; Musante, AM; Obar, RA; Rawson, AP; Rossetti, BJ; Gibbons, IR; Hoffman, MP; Leone, A; Istrail, S; Materna, SC; Samanta, MP; Stolc, V; Tongprasit, W; Tu, Q; Bergeron, K-F; Brandhorst, BP; Whittle, J; Berney, K; Bottjer, DJ; Calestani, C; Peterson, K; Chow, E; Yuan, QA; Elhaik, E; Graur, D; Reese, JT; Bosdet, I; Heesun, S; Marra, MA; Schein, J; Anderson, MK; Brockton, V; Buckley, KM; Cohen, AH; Fugmann, SD; Hibino, T; Loza-Coll, M; Majeske, AJ; Messier, C; Nair, SV; Pancer, Z; Terwilliger, DP; Agca, C; Arboleda, E; Chen, N; Churcher, AM; Hallböök, F; Humphrey, GW; Idris, MM; Kiyama, T; Liang, S; Mellott, D; Mu, X; Murray, G; Olinski, RP; Raible, F; Rowe, M; Taylor, JS; Tessmar-Raible, K; Wang, D; Wilson, KH; Yaguchi, S; Gaasterland, T; Galindo, BE; Gunaratne, HJ; Juliano, C; Kinukawa, M; Moy, GW; Neill, AT; Nomura, M; Raisch, M; Reade, A; Roux, MM; Song, JL; Su, Y-H; Townley, IK; Voronina, E; Wong, JL; Amore, G; Branno, M; Brown, ER; Cavalieri, V; Duboc, V; Duloquin, L; Flytzanis, C; Gache, C; Lapraz, F; Lepage, T; Locascio, A; Martinez, P; Matassi, G; Matranga, V; Range, R; Rizzo, F; Röttinger, E; Beane, W; Bradham, C; Byrum, C; Glenn, T; Hussain, S; Manning, G; Miranda, E; Thomason, R; Walton, K; Wikramanayke, A; Wu, S-Y; Xu, R; Brown, CT; Chen, L; Gray, RF; Lee, PY; Nam, J; Oliveri, P; Smith, J; Muzny, D; Bell, S; Chacko, J; Cree, A; Curry, S; Davis, C; Dinh, H; Dugan-Rocha, S; Fowler, J; Gill, R; Hamilton, C; Hernandez, J; Hines, S; Hume, J; Jackson, L; Jolivet, A; Kovar, C; Lee, S; Lewis, L; Miner, G; Morgan, M; Nazareth, LV; Okwuonu, G; Parker, D; Pu, L-L; Thorn, R; Wright, R

Published Date

  • November 2006

Published In

Volume / Issue

  • 314 / 5801

Start / End Page

  • 941 - 952

PubMed ID

  • 17095691

Pubmed Central ID

  • 17095691

Electronic International Standard Serial Number (EISSN)

  • 1095-9203

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.1133609

Language

  • eng