Invasive non-Aspergillus mold infections in transplant recipients, United States, 2001-2006.

Published

Journal Article

Recent reports describe increasing incidence of non-Aspergillus mold infections in hematopoietic cell transplant (HCT) and solid organ transplant (SOT) recipients. To investigate the epidemiology of infections with Mucorales, Fusarium spp., and Scedosporium spp. molds, we analyzed data from the Transplant-Associated Infection Surveillance Network, 23 transplant centers that conducted prospective surveillance for invasive fungal infections during 2001-2006. We identified 169 infections (105 Mucorales, 37 Fusarium spp., and 27 Scedosporium spp.) in 169 patients; 124 (73.4%) were in HCT recipients, and 45 (26.6%) were in SOT recipients. The crude 90-day mortality rate was 56.6%. The 12-month mucormycosis cumulative incidence was 0.29% for HCT and 0.07% for SOT. Mucormycosis incidence among HCT recipients varied widely, from 0.08% to 0.69%, with higher incidence in cohorts receiving transplants during 2003 and 2004. Non-Aspergillus mold infections continue to be associated with high mortality rates. The incidence of mucormycosis in HCT recipients increased substantially during the surveillance period.

Full Text

Duke Authors

Cited Authors

  • Park, BJ; Pappas, PG; Wannemuehler, KA; Alexander, BD; Anaissie, EJ; Andes, DR; Baddley, JW; Brown, JM; Brumble, LM; Freifeld, AG; Hadley, S; Herwaldt, L; Ito, JI; Kauffman, CA; Lyon, GM; Marr, KA; Morrison, VA; Papanicolaou, G; Patterson, TF; Perl, TM; Schuster, MG; Walker, R; Wingard, JR; Walsh, TJ; Kontoyiannis, DP

Published Date

  • October 2011

Published In

Volume / Issue

  • 17 / 10

Start / End Page

  • 1855 - 1864

PubMed ID

  • 22000355

Pubmed Central ID

  • 22000355

Electronic International Standard Serial Number (EISSN)

  • 1080-6059

Digital Object Identifier (DOI)

  • 10.3201/eid1710.110087

Language

  • eng

Conference Location

  • United States