Significance of blood stream infection after lung transplantation: analysis in 176 consecutive patients.

Journal Article

BACKGROUND: Although infection is a leading cause of death after lung transplantation, very little is known about the incidence, epidemiology, and clinical significance of bloodstream infections in lung transplant recipients. METHODS: All blood cultures were reviewed in 176 consecutive lung transplant recipients over a 6-year period. Data were obtained from a prospectively collected microbiological database. RESULTS: Bloodstream infection (BSI) occurred in 25% (44/176) of all lung transplant recipients over the 6-year study period. Staphylococcus aureus, Pseudomonas aeruginosa, and Candida species were the most common bloodstream isolates after lung transplantation. The epidemiology of posttransplant BSI, however, varied considerably between early and late posttransplant time periods and also differed between cystic fibrosis (CF) and non-CF patients. BSI infection after transplantation was associated with significantly worse survival by Kaplan-Meir analysis (P value log rank test=0.0001). In a multivariable logistic regression model, posttransplant BSI was a significant predictor of posttransplant death (odds ratio 5.62, CI 2.41-13.11, P=0.001), independent of other pre- and posttransplant factors. CONCLUSIONS: Bloodstream infection represents a serious complication after lung transplantation, occurring more frequently than previously recognized, and independently contributing to posttransplant mortality.

Full Text

Duke Authors

Cited Authors

  • Palmer, SM; Alexander, BD; Sanders, LL; Edwards, LJ; Reller, LB; Davis, RD; Tapson, VF

Published Date

  • June 15, 2000

Published In

Volume / Issue

  • 69 / 11

Start / End Page

  • 2360 - 2366

PubMed ID

  • 10868641

International Standard Serial Number (ISSN)

  • 0041-1337

Language

  • eng

Conference Location

  • United States