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Significance of blood stream infection after lung transplantation: analysis in 176 consecutive patients.

Publication ,  Journal Article
Palmer, SM; Alexander, BD; Sanders, LL; Edwards, LJ; Reller, LB; Davis, RD; Tapson, VF
Published in: Transplantation
June 15, 2000

BACKGROUND: Although infection is a leading cause of death after lung transplantation, very little is known about the incidence, epidemiology, and clinical significance of bloodstream infections in lung transplant recipients. METHODS: All blood cultures were reviewed in 176 consecutive lung transplant recipients over a 6-year period. Data were obtained from a prospectively collected microbiological database. RESULTS: Bloodstream infection (BSI) occurred in 25% (44/176) of all lung transplant recipients over the 6-year study period. Staphylococcus aureus, Pseudomonas aeruginosa, and Candida species were the most common bloodstream isolates after lung transplantation. The epidemiology of posttransplant BSI, however, varied considerably between early and late posttransplant time periods and also differed between cystic fibrosis (CF) and non-CF patients. BSI infection after transplantation was associated with significantly worse survival by Kaplan-Meir analysis (P value log rank test=0.0001). In a multivariable logistic regression model, posttransplant BSI was a significant predictor of posttransplant death (odds ratio 5.62, CI 2.41-13.11, P=0.001), independent of other pre- and posttransplant factors. CONCLUSIONS: Bloodstream infection represents a serious complication after lung transplantation, occurring more frequently than previously recognized, and independently contributing to posttransplant mortality.

Duke Scholars

Published In

Transplantation

DOI

ISSN

0041-1337

Publication Date

June 15, 2000

Volume

69

Issue

11

Start / End Page

2360 / 2366

Location

United States

Related Subject Headings

  • Survival Analysis
  • Surgery
  • Sepsis
  • Postoperative Complications
  • Mortality
  • Middle Aged
  • Male
  • Lung Transplantation
  • Incidence
  • Humans
 

Citation

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Palmer, S. M., Alexander, B. D., Sanders, L. L., Edwards, L. J., Reller, L. B., Davis, R. D., & Tapson, V. F. (2000). Significance of blood stream infection after lung transplantation: analysis in 176 consecutive patients. Transplantation, 69(11), 2360–2366. https://doi.org/10.1097/00007890-200006150-00025
Palmer, S. M., B. D. Alexander, L. L. Sanders, L. J. Edwards, L. B. Reller, R. D. Davis, and V. F. Tapson. “Significance of blood stream infection after lung transplantation: analysis in 176 consecutive patients.Transplantation 69, no. 11 (June 15, 2000): 2360–66. https://doi.org/10.1097/00007890-200006150-00025.
Palmer SM, Alexander BD, Sanders LL, Edwards LJ, Reller LB, Davis RD, et al. Significance of blood stream infection after lung transplantation: analysis in 176 consecutive patients. Transplantation. 2000 Jun 15;69(11):2360–6.
Palmer, S. M., et al. “Significance of blood stream infection after lung transplantation: analysis in 176 consecutive patients.Transplantation, vol. 69, no. 11, June 2000, pp. 2360–66. Pubmed, doi:10.1097/00007890-200006150-00025.
Palmer SM, Alexander BD, Sanders LL, Edwards LJ, Reller LB, Davis RD, Tapson VF. Significance of blood stream infection after lung transplantation: analysis in 176 consecutive patients. Transplantation. 2000 Jun 15;69(11):2360–2366.

Published In

Transplantation

DOI

ISSN

0041-1337

Publication Date

June 15, 2000

Volume

69

Issue

11

Start / End Page

2360 / 2366

Location

United States

Related Subject Headings

  • Survival Analysis
  • Surgery
  • Sepsis
  • Postoperative Complications
  • Mortality
  • Middle Aged
  • Male
  • Lung Transplantation
  • Incidence
  • Humans