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Cryptococcus neoformans isolates from transplant recipients are not selected for resistance to calcineurin inhibitors by current immunosuppressive regimens.

Publication ,  Journal Article
Blankenship, JR; Singh, N; Alexander, BD; Heitman, J
Published in: J Clin Microbiol
January 2005

The immunosuppressants tacrolimus (FK506) and cyclosporine A inhibit calcineurin and have potent antifungal activity. In this study, 24% of Cryptococcus neoformans isolates from solid-organ transplant patients exhibited altered sensitivity to these drugs, which may have an impact on the infectious course but does not appear to be the consequence of immunosuppressive therapy.

Duke Scholars

Published In

J Clin Microbiol

DOI

ISSN

0095-1137

Publication Date

January 2005

Volume

43

Issue

1

Start / End Page

464 / 467

Location

United States

Related Subject Headings

  • Tacrolimus
  • Organ Transplantation
  • Microbiology
  • Microbial Sensitivity Tests
  • Immunosuppressive Agents
  • Humans
  • Drug Resistance, Fungal
  • Cyclosporine
  • Cryptococcus neoformans
  • Cryptococcosis
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Blankenship, J. R., Singh, N., Alexander, B. D., & Heitman, J. (2005). Cryptococcus neoformans isolates from transplant recipients are not selected for resistance to calcineurin inhibitors by current immunosuppressive regimens. J Clin Microbiol, 43(1), 464–467. https://doi.org/10.1128/JCM.43.1.464-467.2005
Blankenship, Jill R., Nina Singh, Barbara D. Alexander, and Joseph Heitman. “Cryptococcus neoformans isolates from transplant recipients are not selected for resistance to calcineurin inhibitors by current immunosuppressive regimens.J Clin Microbiol 43, no. 1 (January 2005): 464–67. https://doi.org/10.1128/JCM.43.1.464-467.2005.
Blankenship, Jill R., et al. “Cryptococcus neoformans isolates from transplant recipients are not selected for resistance to calcineurin inhibitors by current immunosuppressive regimens.J Clin Microbiol, vol. 43, no. 1, Jan. 2005, pp. 464–67. Pubmed, doi:10.1128/JCM.43.1.464-467.2005.

Published In

J Clin Microbiol

DOI

ISSN

0095-1137

Publication Date

January 2005

Volume

43

Issue

1

Start / End Page

464 / 467

Location

United States

Related Subject Headings

  • Tacrolimus
  • Organ Transplantation
  • Microbiology
  • Microbial Sensitivity Tests
  • Immunosuppressive Agents
  • Humans
  • Drug Resistance, Fungal
  • Cyclosporine
  • Cryptococcus neoformans
  • Cryptococcosis