Cryptococcus neoformans isolates from transplant recipients are not selected for resistance to calcineurin inhibitors by current immunosuppressive regimens.

Journal Article (Journal Article)

The immunosuppressants tacrolimus (FK506) and cyclosporine A inhibit calcineurin and have potent antifungal activity. In this study, 24% of Cryptococcus neoformans isolates from solid-organ transplant patients exhibited altered sensitivity to these drugs, which may have an impact on the infectious course but does not appear to be the consequence of immunosuppressive therapy.

Full Text

Duke Authors

Cited Authors

  • Blankenship, JR; Singh, N; Alexander, BD; Heitman, J

Published Date

  • January 2005

Published In

Volume / Issue

  • 43 / 1

Start / End Page

  • 464 - 467

PubMed ID

  • 15635017

Pubmed Central ID

  • PMC540157

International Standard Serial Number (ISSN)

  • 0095-1137

Digital Object Identifier (DOI)

  • 10.1128/JCM.43.1.464-467.2005


  • eng

Conference Location

  • United States