Cryptococcus neoformans isolates from transplant recipients are not selected for resistance to calcineurin inhibitors by current immunosuppressive regimens.
Publication
, Journal Article
Blankenship, JR; Singh, N; Alexander, BD; Heitman, J
Published in: J Clin Microbiol
January 2005
The immunosuppressants tacrolimus (FK506) and cyclosporine A inhibit calcineurin and have potent antifungal activity. In this study, 24% of Cryptococcus neoformans isolates from solid-organ transplant patients exhibited altered sensitivity to these drugs, which may have an impact on the infectious course but does not appear to be the consequence of immunosuppressive therapy.
Duke Scholars
Published In
J Clin Microbiol
DOI
ISSN
0095-1137
Publication Date
January 2005
Volume
43
Issue
1
Start / End Page
464 / 467
Location
United States
Related Subject Headings
- Tacrolimus
- Organ Transplantation
- Microbiology
- Microbial Sensitivity Tests
- Immunosuppressive Agents
- Humans
- Drug Resistance, Fungal
- Cyclosporine
- Cryptococcus neoformans
- Cryptococcosis
Citation
APA
Chicago
ICMJE
MLA
NLM
Blankenship, J. R., Singh, N., Alexander, B. D., & Heitman, J. (2005). Cryptococcus neoformans isolates from transplant recipients are not selected for resistance to calcineurin inhibitors by current immunosuppressive regimens. J Clin Microbiol, 43(1), 464–467. https://doi.org/10.1128/JCM.43.1.464-467.2005
Blankenship, Jill R., Nina Singh, Barbara D. Alexander, and Joseph Heitman. “Cryptococcus neoformans isolates from transplant recipients are not selected for resistance to calcineurin inhibitors by current immunosuppressive regimens.” J Clin Microbiol 43, no. 1 (January 2005): 464–67. https://doi.org/10.1128/JCM.43.1.464-467.2005.
Blankenship JR, Singh N, Alexander BD, Heitman J. Cryptococcus neoformans isolates from transplant recipients are not selected for resistance to calcineurin inhibitors by current immunosuppressive regimens. J Clin Microbiol. 2005 Jan;43(1):464–7.
Blankenship, Jill R., et al. “Cryptococcus neoformans isolates from transplant recipients are not selected for resistance to calcineurin inhibitors by current immunosuppressive regimens.” J Clin Microbiol, vol. 43, no. 1, Jan. 2005, pp. 464–67. Pubmed, doi:10.1128/JCM.43.1.464-467.2005.
Blankenship JR, Singh N, Alexander BD, Heitman J. Cryptococcus neoformans isolates from transplant recipients are not selected for resistance to calcineurin inhibitors by current immunosuppressive regimens. J Clin Microbiol. 2005 Jan;43(1):464–467.
Published In
J Clin Microbiol
DOI
ISSN
0095-1137
Publication Date
January 2005
Volume
43
Issue
1
Start / End Page
464 / 467
Location
United States
Related Subject Headings
- Tacrolimus
- Organ Transplantation
- Microbiology
- Microbial Sensitivity Tests
- Immunosuppressive Agents
- Humans
- Drug Resistance, Fungal
- Cyclosporine
- Cryptococcus neoformans
- Cryptococcosis