Rationale for reading fluconazole MICs at 24 hours rather than 48 hours when testing Candida spp. by the CLSI M27-A2 standard method.

Journal Article (Journal Article)

We investigated if CLSI M27-A2 Candida species breakpoints for fluconazole MIC are valid when read at 24 h. Analysis of a data set showed good correlation between 48- and 24-h MICs, as well as similar outcomes and pharmacodynamic efficacy parameters, except for isolates in the susceptible dose-dependent category, such as Candida glabrata.

Full Text

Duke Authors

Cited Authors

  • Ostrosky-Zeichner, L; Rex, JH; Pfaller, MA; Diekema, DJ; Alexander, BD; Andes, D; Brown, SD; Chaturvedi, V; Ghannoum, MA; Knapp, CC; Sheehan, DJ; Walsh, TJ

Published Date

  • November 2008

Published In

Volume / Issue

  • 52 / 11

Start / End Page

  • 4175 - 4177

PubMed ID

  • 18809944

Pubmed Central ID

  • PMC2573146

Electronic International Standard Serial Number (EISSN)

  • 1098-6596

Digital Object Identifier (DOI)

  • 10.1128/AAC.00420-08


  • eng

Conference Location

  • United States