Rationale for reading fluconazole MICs at 24 hours rather than 48 hours when testing Candida spp. by the CLSI M27-A2 standard method.
We investigated if CLSI M27-A2 Candida species breakpoints for fluconazole MIC are valid when read at 24 h. Analysis of a data set showed good correlation between 48- and 24-h MICs, as well as similar outcomes and pharmacodynamic efficacy parameters, except for isolates in the susceptible dose-dependent category, such as Candida glabrata.
Ostrosky-Zeichner, L; Rex, JH; Pfaller, MA; Diekema, DJ; Alexander, BD; Andes, D; Brown, SD; Chaturvedi, V; Ghannoum, MA; Knapp, CC; Sheehan, DJ; Walsh, TJ
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