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Opportunistic mycelial fungal infections in organ transplant recipients: emerging importance of non-Aspergillus mycelial fungi.

Publication ,  Journal Article
Husain, S; Alexander, BD; Munoz, P; Avery, RK; Houston, S; Pruett, T; Jacobs, R; Dominguez, EA; Tollemar, JG; Baumgarten, K; Yu, CM; Linden, P ...
Published in: Clin Infect Dis
July 15, 2003

To determine the spectrum and impact of mycelial fungal infections, particularly those due to non-Aspergillus molds, 53 liver and heart transplant recipients with invasive mycelial infections were prospectively identified in a multicenter study. Invasive mycelial infections were due to Aspergillus species in 69.8% of patients, to non-Aspergillus hyalohyphomycetes in 9.4%, to phaeohyphomycetes in 9.4%, to zygomycetes in 5.7%, and to other causes in 5.7%. Infections due to mycelial fungi other than Aspergillus species were significantly more likely to be associated with disseminated (P=.005) and central nervous system (P=.07) infection than were those due to Aspergillus species. Overall mortality at 90 days was 54.7%. The associated mortality rate was 100% for zygomycosis, 80% for non-Aspergillus hyalohyphomycosis, 54% for aspergillosis, and 20% for phaeohyphomycosis. Thus, non-Aspergillus molds have emerged as significant pathogens in organ transplant recipients. These molds are more likely to be associated with disseminated infections and to be associated with poorer outcomes than is aspergillosis.

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Published In

Clin Infect Dis

DOI

EISSN

1537-6591

Publication Date

July 15, 2003

Volume

37

Issue

2

Start / End Page

221 / 229

Location

United States

Related Subject Headings

  • Prospective Studies
  • Postoperative Complications
  • Outcome and Process Assessment, Health Care
  • Organ Transplantation
  • Opportunistic Infections
  • Mycoses
  • Middle Aged
  • Microbiology
  • Humans
  • Candidiasis
 

Citation

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Chicago
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Husain, S., Alexander, B. D., Munoz, P., Avery, R. K., Houston, S., Pruett, T., … Singh, N. (2003). Opportunistic mycelial fungal infections in organ transplant recipients: emerging importance of non-Aspergillus mycelial fungi. Clin Infect Dis, 37(2), 221–229. https://doi.org/10.1086/375822
Husain, Shahid, Barbara D. Alexander, Patricia Munoz, Robin K. Avery, Sally Houston, Timothy Pruett, Richard Jacobs, et al. “Opportunistic mycelial fungal infections in organ transplant recipients: emerging importance of non-Aspergillus mycelial fungi.Clin Infect Dis 37, no. 2 (July 15, 2003): 221–29. https://doi.org/10.1086/375822.
Husain S, Alexander BD, Munoz P, Avery RK, Houston S, Pruett T, et al. Opportunistic mycelial fungal infections in organ transplant recipients: emerging importance of non-Aspergillus mycelial fungi. Clin Infect Dis. 2003 Jul 15;37(2):221–9.
Husain, Shahid, et al. “Opportunistic mycelial fungal infections in organ transplant recipients: emerging importance of non-Aspergillus mycelial fungi.Clin Infect Dis, vol. 37, no. 2, July 2003, pp. 221–29. Pubmed, doi:10.1086/375822.
Husain S, Alexander BD, Munoz P, Avery RK, Houston S, Pruett T, Jacobs R, Dominguez EA, Tollemar JG, Baumgarten K, Yu CM, Wagener MM, Linden P, Kusne S, Singh N. Opportunistic mycelial fungal infections in organ transplant recipients: emerging importance of non-Aspergillus mycelial fungi. Clin Infect Dis. 2003 Jul 15;37(2):221–229.
Journal cover image

Published In

Clin Infect Dis

DOI

EISSN

1537-6591

Publication Date

July 15, 2003

Volume

37

Issue

2

Start / End Page

221 / 229

Location

United States

Related Subject Headings

  • Prospective Studies
  • Postoperative Complications
  • Outcome and Process Assessment, Health Care
  • Organ Transplantation
  • Opportunistic Infections
  • Mycoses
  • Middle Aged
  • Microbiology
  • Humans
  • Candidiasis