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Caspofungin for invasive candidiasis at a tertiary care medical center.

Publication ,  Journal Article
Zaas, AK; Dodds Ashley, ES; Alexander, BD; Johnson, MD; Perfect, JR
Published in: Am J Med
November 2006

BACKGROUND: Caspofungin is emerging as first-line therapy for invasive candidiasis. Data on the use of caspofungin for treatment for invasive candidiasis are limited to clinical trials and case reports. We report a single-center experience with 104 consecutive courses of caspofungin for the treatment of invasive candidiasis to evaluate a real-world performance of this drug. METHODS: A retrospective chart review of patients receiving caspofungin at a tertiary care medical center was performed. Patient information and microbiologic data were abstracted from patient charts and electronic medical records. RESULTS: Of 241 patients receiving caspofungin for all indications, 122 (51%) had proven invasive candidiasis. There were 104 treatment courses for candidiasis in 99 patients available for review. Bloodstream (66%) and abdominal infections (25%) were the most common sites of infection. Most infections were non-albicans (80/104, 77%; including patients infected with more than one species). Clinical cure rates at the end of therapy were 83% (57/69) for bloodstream infections and 84% (22/26) for abdominal infections. Caspofungin did not clear candidiasis in 14 episodes (microbiologic cure rate 75%, 42/56). CONCLUSIONS: The clinical use of caspofungin has been successful in the treatment of invasive candidiasis, even in patients with prior antifungal exposure. In this unselected review, caspofungin performed similarly as in clinical trials, and clinicians should consider caspofungin as first-line therapy for invasive candidiasis, particularly non-albicans species.

Duke Scholars

Published In

Am J Med

DOI

EISSN

1555-7162

Publication Date

November 2006

Volume

119

Issue

11

Start / End Page

993.e1 / 993.e6

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Severity of Illness Index
  • Retrospective Studies
  • Peptides, Cyclic
  • North Carolina
  • Medical Records
  • Male
  • Lipopeptides
  • Humans
  • General & Internal Medicine
 

Citation

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Zaas, A. K., Dodds Ashley, E. S., Alexander, B. D., Johnson, M. D., & Perfect, J. R. (2006). Caspofungin for invasive candidiasis at a tertiary care medical center. Am J Med, 119(11), 993.e1-993.e6. https://doi.org/10.1016/j.amjmed.2006.02.029
Zaas, Aimee K., Elizabeth S. Dodds Ashley, Barbara D. Alexander, Melissa D. Johnson, and John R. Perfect. “Caspofungin for invasive candidiasis at a tertiary care medical center.Am J Med 119, no. 11 (November 2006): 993.e1-993.e6. https://doi.org/10.1016/j.amjmed.2006.02.029.
Zaas AK, Dodds Ashley ES, Alexander BD, Johnson MD, Perfect JR. Caspofungin for invasive candidiasis at a tertiary care medical center. Am J Med. 2006 Nov;119(11):993.e1-993.e6.
Zaas, Aimee K., et al. “Caspofungin for invasive candidiasis at a tertiary care medical center.Am J Med, vol. 119, no. 11, Nov. 2006, pp. 993.e1-993.e6. Pubmed, doi:10.1016/j.amjmed.2006.02.029.
Zaas AK, Dodds Ashley ES, Alexander BD, Johnson MD, Perfect JR. Caspofungin for invasive candidiasis at a tertiary care medical center. Am J Med. 2006 Nov;119(11):993.e1-993.e6.
Journal cover image

Published In

Am J Med

DOI

EISSN

1555-7162

Publication Date

November 2006

Volume

119

Issue

11

Start / End Page

993.e1 / 993.e6

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Severity of Illness Index
  • Retrospective Studies
  • Peptides, Cyclic
  • North Carolina
  • Medical Records
  • Male
  • Lipopeptides
  • Humans
  • General & Internal Medicine