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In vitro characterization of nebulizer delivery of liposomal amphotericin B aerosols.

Publication ,  Journal Article
Alexander, BD; Winkler, TP; Shi, S; Dodds Ashley, ES; Hickey, AJ
Published in: Pharm Dev Technol
2011

Pharmaceutical aerosols have the potential to prevent pulmonary infectious diseases. Liposomal amphotericin B (LAMB, Ambisome, Astellas Pharma US, Deerfield, IL, USA) is approved as an intravenous infusion for empiric treatment of presumed fungal infections in neutropenic, febrile patients, as well as patients infected with Aspergillus, Cryptococcus, and other fungal pathogens. In this study, four different nebulizers were tested for their ability to deliver LAMB in aerodynamic droplet-size ranges relevant to lung deposition by an inertial sampling technique Mass median aerodynamic diameter (MMAD) and fine particle fraction percent <3.3 μm (FPF(3.3)) and <5.8 μm (FPF(5.8)) were determined by cascade impaction during a 2 min sampling period for each of three trials of all nebulizers. The MMADs for all nebulizers ranged from 1.72 ± 0.11 μm to 2.89 ± 0.12 μm; FPF(3.3) and FPF(5.8) were approximately 80% and 90%, respectively. Although all nebulizers appear acceptable for delivery of LAMB, the Pari LC Star and the Aeroeclipse II were considered the best in terms of delivery of aerosol efficiently and the proportion suitable for lung deposition. Additional research on pulmonary delivery and clinical tolerability is warranted.

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Published In

Pharm Dev Technol

DOI

EISSN

1097-9867

Publication Date

2011

Volume

16

Issue

6

Start / End Page

577 / 582

Location

England

Related Subject Headings

  • Pharmacology & Pharmacy
  • Particle Size
  • Nebulizers and Vaporizers
  • Equipment Design
  • Drug Delivery Systems
  • Antifungal Agents
  • Amphotericin B
  • Aerosols
  • Administration, Inhalation
  • 3214 Pharmacology and pharmaceutical sciences
 

Citation

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Alexander, B. D., Winkler, T. P., Shi, S., Dodds Ashley, E. S., & Hickey, A. J. (2011). In vitro characterization of nebulizer delivery of liposomal amphotericin B aerosols. Pharm Dev Technol, 16(6), 577–582. https://doi.org/10.3109/10837450.2011.591803
Alexander, Barbara D., Thomas P. Winkler, Shuai Shi, Elizabeth S. Dodds Ashley, and Anthony J. Hickey. “In vitro characterization of nebulizer delivery of liposomal amphotericin B aerosols.Pharm Dev Technol 16, no. 6 (2011): 577–82. https://doi.org/10.3109/10837450.2011.591803.
Alexander BD, Winkler TP, Shi S, Dodds Ashley ES, Hickey AJ. In vitro characterization of nebulizer delivery of liposomal amphotericin B aerosols. Pharm Dev Technol. 2011;16(6):577–82.
Alexander, Barbara D., et al. “In vitro characterization of nebulizer delivery of liposomal amphotericin B aerosols.Pharm Dev Technol, vol. 16, no. 6, 2011, pp. 577–82. Pubmed, doi:10.3109/10837450.2011.591803.
Alexander BD, Winkler TP, Shi S, Dodds Ashley ES, Hickey AJ. In vitro characterization of nebulizer delivery of liposomal amphotericin B aerosols. Pharm Dev Technol. 2011;16(6):577–582.

Published In

Pharm Dev Technol

DOI

EISSN

1097-9867

Publication Date

2011

Volume

16

Issue

6

Start / End Page

577 / 582

Location

England

Related Subject Headings

  • Pharmacology & Pharmacy
  • Particle Size
  • Nebulizers and Vaporizers
  • Equipment Design
  • Drug Delivery Systems
  • Antifungal Agents
  • Amphotericin B
  • Aerosols
  • Administration, Inhalation
  • 3214 Pharmacology and pharmaceutical sciences