Molecular identification of Aspergillus species collected for the Transplant-Associated Infection Surveillance Network.

Published

Journal Article

A large aggregate collection of clinical isolates of aspergilli (n = 218) from transplant patients with proven or probable invasive aspergillosis was available from the Transplant-Associated Infection Surveillance Network, a 6-year prospective surveillance study. To determine the Aspergillus species distribution in this collection, isolates were subjected to comparative sequence analyses by use of the internal transcribed spacer and beta-tubulin regions. Aspergillus fumigatus was the predominant species recovered, followed by A. flavus and A. niger. Several newly described species were identified, including A. lentulus and A. calidoustus; both species had high in vitro MICs to multiple antifungal drugs. Aspergillus tubingensis, a member of the A. niger species complex, is described from clinical specimens; all A. tubingensis isolates had low in vitro MICs to antifungal drugs.

Full Text

Duke Authors

Cited Authors

  • Balajee, SA; Kano, R; Baddley, JW; Moser, SA; Marr, KA; Alexander, BD; Andes, D; Kontoyiannis, DP; Perrone, G; Peterson, S; Brandt, ME; Pappas, PG; Chiller, T

Published Date

  • October 2009

Published In

Volume / Issue

  • 47 / 10

Start / End Page

  • 3138 - 3141

PubMed ID

  • 19675215

Pubmed Central ID

  • 19675215

Electronic International Standard Serial Number (EISSN)

  • 1098-660X

Digital Object Identifier (DOI)

  • 10.1128/JCM.01070-09

Language

  • eng

Conference Location

  • United States