Cryptococcus neoformans in organ transplant recipients: impact of calcineurin-inhibitor agents on mortality.
Variables influencing the risk of dissemination and outcome of Cryptococcus neoformans infection were assessed in 111 organ transplant recipients with cryptococcosis in a prospective, multicenter, international study. Sixty-one percent (68/111) of the patients had disseminated infection. The risk of disseminated cryptococcosis was significantly higher for liver transplant recipients (adjusted hazard ratio [HR], 6.65; P=.048). The overall mortality rate at 90 days was 14% (16/111). The mortality rate was higher in patients with abnormal mental status (P=.023), renal failure at baseline (P=.028), fungemia (P=.006), and disseminated infection (P=.035) and was lower in those receiving a calcineurin-inhibitor agent (P=.003). In a multivariable analysis, the receipt of a calcineurin-inhibitor agent was independently associated with a lower mortality (adjusted HR, 0.21; P=.008), and renal failure at baseline with a higher mortality rate (adjusted HR, 3.14; P=.037). Thus, outcome in transplant recipients with cryptococcosis appears to be influenced by the type of immunosuppressive agent employed. Additionally, discerning the basis for transplant type-specific differences in disease severity has implications relevant for yielding further insights into the pathogenesis of C. neoformans infection in transplant recipients.
Singh, N; Alexander, BD; Lortholary, O; Dromer, F; Gupta, KL; John, GT; del Busto, R; Klintmalm, GB; Somani, J; Lyon, GM; Pursell, K; Stosor, V; Munoz, P; Limaye, AP; Kalil, AC; Pruett, TL; Garcia-Diaz, J; Humar, A; Houston, S; House, AA; Wray, D; Orloff, S; Dowdy, LA; Fisher, RA; Heitman, J; Wagener, MM; Husain, S; Cryptococcal Collaborative Transplant Study Group,
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