Calcineurin inhibitor agents interact synergistically with antifungal agents in vitro against Cryptococcus neoformans isolates: correlation with outcome in solid organ transplant recipients with cryptococcosis.

Journal Article (Journal Article)

Synergistic interactions were observed between CIs and antifungal agents against 53 (90%) of 59 Cryptococcus neoformans isolates from solid organ transplant recipients with cryptococcosis and may account for better outcomes in patients with cryptococcosis receiving these immunosuppressive agents.

Full Text

Duke Authors

Cited Authors

  • Kontoyiannis, DP; Lewis, RE; Alexander, BD; Lortholary, O; Dromer, F; Gupta, KL; John, GT; Del Busto, R; Klintmalm, GB; Somani, J; Lyon, GM; Pursell, K; Stosor, V; Munoz, P; Limaye, AP; Kalil, AC; Pruett, TL; Garcia-Diaz, J; Humar, A; Houston, S; House, AA; Wray, D; Orloff, S; Dowdy, LA; Fisher, RA; Heitman, J; Albert, ND; Wagener, MM; Singh, N

Published Date

  • February 2008

Published In

Volume / Issue

  • 52 / 2

Start / End Page

  • 735 - 738

PubMed ID

  • 18070977

Pubmed Central ID

  • PMC2224743

International Standard Serial Number (ISSN)

  • 0066-4804

Digital Object Identifier (DOI)

  • 10.1128/AAC.00990-07


  • eng

Conference Location

  • United States