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ITPA gene variants protect against anaemia in patients treated for chronic hepatitis C.

Publication ,  Journal Article
Fellay, J; Thompson, AJ; Ge, D; Gumbs, CE; Urban, TJ; Shianna, KV; Little, LD; Qiu, P; Bertelsen, AH; Watson, M; Warner, A; Muir, AJ ...
Published in: Nature
March 18, 2010

Chronic infection with the hepatitis C virus (HCV) affects 170 million people worldwide and is an important cause of liver-related morbidity and mortality. The standard of care therapy combines pegylated interferon (pegIFN) alpha and ribavirin (RBV), and is associated with a range of treatment-limiting adverse effects. One of the most important of these is RBV-induced haemolytic anaemia, which affects most patients and is severe enough to require dose modification in up to 15% of patients. Here we show that genetic variants leading to inosine triphosphatase deficiency, a condition not thought to be clinically important, protect against haemolytic anaemia in hepatitis-C-infected patients receiving RBV.

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Published In

Nature

DOI

EISSN

1476-4687

Publication Date

March 18, 2010

Volume

464

Issue

7287

Start / End Page

405 / 408

Location

England

Related Subject Headings

  • United States
  • Ribavirin
  • Racial Groups
  • Pyrophosphatases
  • Polymorphism, Single Nucleotide
  • Inosine Triphosphatase
  • Humans
  • Hepatitis C, Chronic
  • Hemoglobins
  • Genome-Wide Association Study
 

Citation

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Fellay, J., Thompson, A. J., Ge, D., Gumbs, C. E., Urban, T. J., Shianna, K. V., … Goldstein, D. B. (2010). ITPA gene variants protect against anaemia in patients treated for chronic hepatitis C. Nature, 464(7287), 405–408. https://doi.org/10.1038/nature08825
Fellay, Jacques, Alexander J. Thompson, Dongliang Ge, Curtis E. Gumbs, Thomas J. Urban, Kevin V. Shianna, Latasha D. Little, et al. “ITPA gene variants protect against anaemia in patients treated for chronic hepatitis C.Nature 464, no. 7287 (March 18, 2010): 405–8. https://doi.org/10.1038/nature08825.
Fellay J, Thompson AJ, Ge D, Gumbs CE, Urban TJ, Shianna KV, et al. ITPA gene variants protect against anaemia in patients treated for chronic hepatitis C. Nature. 2010 Mar 18;464(7287):405–8.
Fellay, Jacques, et al. “ITPA gene variants protect against anaemia in patients treated for chronic hepatitis C.Nature, vol. 464, no. 7287, Mar. 2010, pp. 405–08. Pubmed, doi:10.1038/nature08825.
Fellay J, Thompson AJ, Ge D, Gumbs CE, Urban TJ, Shianna KV, Little LD, Qiu P, Bertelsen AH, Watson M, Warner A, Muir AJ, Brass C, Albrecht J, Sulkowski M, McHutchison JG, Goldstein DB. ITPA gene variants protect against anaemia in patients treated for chronic hepatitis C. Nature. 2010 Mar 18;464(7287):405–408.
Journal cover image

Published In

Nature

DOI

EISSN

1476-4687

Publication Date

March 18, 2010

Volume

464

Issue

7287

Start / End Page

405 / 408

Location

England

Related Subject Headings

  • United States
  • Ribavirin
  • Racial Groups
  • Pyrophosphatases
  • Polymorphism, Single Nucleotide
  • Inosine Triphosphatase
  • Humans
  • Hepatitis C, Chronic
  • Hemoglobins
  • Genome-Wide Association Study