The use of hydroxocobalamin in the prophylaxis and treatment of nitroprusside-induced cyanide toxicity.

Journal Article (Journal Article)

The use of OHB12 in the prophylaxis of CN intoxication resulting from SNP infusions is well documented in the literature. However, data is lacking to support its use as an antidote once signs and symptoms have developed. Because of the efficacy of oxygen therapy combined with supportive therapy and nitrite/sodium thiosulfate administration, the use of OHB12 as an antidote cannot be recommended at this time. Further studies are needed to determine efficacy, dosing, mode of administration and comparative trials to other antidotes.

Full Text

Duke Authors

Cited Authors

  • Drew, RH

Published Date

  • October 1, 1983

Published In

Volume / Issue

  • 25 / 5

Start / End Page

  • 342 - 345

PubMed ID

  • 6636508

International Standard Serial Number (ISSN)

  • 0145-6296


  • eng

Conference Location

  • United States