A randomized comparative study to determine the effect of omeprazole on the peak serum concentration of itraconazole oral solution.

Journal Article (Clinical Trial;Journal Article)

To determine the effect of omeprazole on peak serum concentrations (C(max)) of itraconazole oral solution (IOS), we carried out a randomized, open-label, prospective, crossover study. Fifteen healthy, non-pregnant adults received a single dose of IOS 400 mg on two occasions, at least 7 days apart, with omeprazole 40 mg nightly for 7 days before either IOS dose 1 or 2. C(max), time to C(max) (T(max)) and AUC(0-8) were determined for itraconazole and its active metabolite, hydroxyitraconazole, for each dose and compared. Omeprazole did not significantly affect the C(max), T(max) or AUC(0-8) of itraconazole or hydroxyitraconazole when administered as IOS.

Full Text

Duke Authors

Cited Authors

  • Johnson, MD; Hamilton, CD; Drew, RH; Sanders, LL; Pennick, GJ; Perfect, JR

Published Date

  • February 2003

Published In

Volume / Issue

  • 51 / 2

Start / End Page

  • 453 - 457

PubMed ID

  • 12562722

Pubmed Central ID

  • PMC4687480

International Standard Serial Number (ISSN)

  • 0305-7453

Digital Object Identifier (DOI)

  • 10.1093/jac/dkg089


  • eng

Conference Location

  • England