A randomized comparative study to determine the effect of omeprazole on the peak serum concentration of itraconazole oral solution.


Journal Article

To determine the effect of omeprazole on peak serum concentrations (C(max)) of itraconazole oral solution (IOS), we carried out a randomized, open-label, prospective, crossover study. Fifteen healthy, non-pregnant adults received a single dose of IOS 400 mg on two occasions, at least 7 days apart, with omeprazole 40 mg nightly for 7 days before either IOS dose 1 or 2. C(max), time to C(max) (T(max)) and AUC(0-8) were determined for itraconazole and its active metabolite, hydroxyitraconazole, for each dose and compared. Omeprazole did not significantly affect the C(max), T(max) or AUC(0-8) of itraconazole or hydroxyitraconazole when administered as IOS.

Full Text

Duke Authors

Cited Authors

  • Johnson, MD; Hamilton, CD; Drew, RH; Sanders, LL; Pennick, GJ; Perfect, JR

Published Date

  • February 2003

Published In

Volume / Issue

  • 51 / 2

Start / End Page

  • 453 - 457

PubMed ID

  • 12562722

Pubmed Central ID

  • 12562722

International Standard Serial Number (ISSN)

  • 0305-7453

Digital Object Identifier (DOI)

  • 10.1093/jac/dkg089


  • eng

Conference Location

  • England