Safety of aerosolized amphotericin B lipid complex in lung transplant recipients.

Published

Journal Article

BACKGROUND: Fungal infections remain an important cause of morbidity and mortality in lung transplant recipients. Aerosolized amphotericin B lipid complex (ABLC) may be more efficacious than conventional amphotericin B in the prevention of fungal infections in animal models, but experience with aerosolized ABLC in humans is lacking. METHODS: We conducted a prospective, noncomparative study designed to evaluate safety of aerosolized ABLC in lung or heart-lung transplant recipients. RESULTS: A total of 381 treatments were administered to 51 patients. Complete spirometry records were available for 335 treatments (69 in intubated patients, 266 in extubated patients). ABLC was subjectively well tolerated in 98% of patients. Pulmonary mechanics worsened by 20% or more posttreatment in less than 5% of all treatments. There were no significant adverse events related to study medication in any patient, and 1-year survival for all enrolled patients was 78%. CONCLUSION: Administration of nebulized ABLC is safe in the short-term and well-tolerated in lung transplant recipients. Additional prospective, randomized studies are needed to determine the efficacy of aerosolized ABLC alone or in conjunction with systemic therapies in the prevention of fungal infections in lung transplant recipients.

Full Text

Duke Authors

Cited Authors

  • Palmer, SM; Drew, RH; Whitehouse, JD; Tapson, VF; Davis, RD; McConnell, RR; Kanj, SS; Perfect, JR

Published Date

  • August 15, 2001

Published In

Volume / Issue

  • 72 / 3

Start / End Page

  • 545 - 548

PubMed ID

  • 11502995

Pubmed Central ID

  • 11502995

International Standard Serial Number (ISSN)

  • 0041-1337

Digital Object Identifier (DOI)

  • 10.1097/00007890-200108150-00036

Language

  • eng

Conference Location

  • United States