Skip to main content
Journal cover image

Neonatal bacterial infection alters fever to live and simulated infections in adulthood.

Publication ,  Journal Article
Bilbo, SD; Wieseler, JL; Barrientos, RM; Tsang, V; Watkins, LR; Maier, SF
Published in: Psychoneuroendocrinology
April 2010

Fever is a critical component of the host immune response to infection. An emerging literature demonstrates that experience with infectious organisms early in life, during the perinatal period, may permanently program immune responses later in life, including fever. We explored the influence of neonatal infection with Escherichia coli on fever responses to lipopolysaccharide (LPS) and E. coli in adulthood. Fever to a low dose of LPS in adulthood did not significantly differ as a consequence of early-life infection. Eight days after the LPS injection, the same group of rats received a high dose of live E. coli. This time, neonatally infected rats exhibited a markedly longer fever than controls. In a subsequent experiment, fever to a single high dose of E. coli without prior LPS in adulthood did not differ by group, suggesting that the previous difference was a lack of tolerance to the dual challenges in early-infected rats. Finally, both groups exhibited decreased tumor necrosis factor (TNF)-alpha and toll-like-receptor (TLR) 4 production to dual LPS challenges in isolated splenocytes, whereas only rats infected as neonates exhibited increased cyclooxygenase-2 within the hypothalamus in response to adult infection, suggesting that early infection-induced changes in fever regulation may involve a change in central mechanisms. Taken together, these data indicate that early-life infection is associated with marked changes in host temperature regulation in adulthood.

Duke Scholars

Published In

Psychoneuroendocrinology

DOI

EISSN

1873-3360

ISSN

0306-4530

Publication Date

April 2010

Volume

35

Issue

3

Start / End Page

369 / 381

Related Subject Headings

  • Weight Loss
  • Rats, Sprague-Dawley
  • Rats
  • Psychiatry
  • Neuroimmunomodulation
  • Male
  • Lipopolysaccharides
  • Inflammation
  • Immunologic Memory
  • Immune Tolerance
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Bilbo, S. D., Wieseler, J. L., Barrientos, R. M., Tsang, V., Watkins, L. R., & Maier, S. F. (2010). Neonatal bacterial infection alters fever to live and simulated infections in adulthood. Psychoneuroendocrinology, 35(3), 369–381. https://doi.org/10.1016/j.psyneuen.2009.07.014
Bilbo, Staci D., Julie L. Wieseler, Ruth M. Barrientos, Verne Tsang, Linda R. Watkins, and Steven F. Maier. “Neonatal bacterial infection alters fever to live and simulated infections in adulthood.Psychoneuroendocrinology 35, no. 3 (April 2010): 369–81. https://doi.org/10.1016/j.psyneuen.2009.07.014.
Bilbo SD, Wieseler JL, Barrientos RM, Tsang V, Watkins LR, Maier SF. Neonatal bacterial infection alters fever to live and simulated infections in adulthood. Psychoneuroendocrinology. 2010 Apr;35(3):369–81.
Bilbo, Staci D., et al. “Neonatal bacterial infection alters fever to live and simulated infections in adulthood.Psychoneuroendocrinology, vol. 35, no. 3, Apr. 2010, pp. 369–81. Epmc, doi:10.1016/j.psyneuen.2009.07.014.
Bilbo SD, Wieseler JL, Barrientos RM, Tsang V, Watkins LR, Maier SF. Neonatal bacterial infection alters fever to live and simulated infections in adulthood. Psychoneuroendocrinology. 2010 Apr;35(3):369–381.
Journal cover image

Published In

Psychoneuroendocrinology

DOI

EISSN

1873-3360

ISSN

0306-4530

Publication Date

April 2010

Volume

35

Issue

3

Start / End Page

369 / 381

Related Subject Headings

  • Weight Loss
  • Rats, Sprague-Dawley
  • Rats
  • Psychiatry
  • Neuroimmunomodulation
  • Male
  • Lipopolysaccharides
  • Inflammation
  • Immunologic Memory
  • Immune Tolerance