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Cardiac arrest/cardiopulmonary resuscitation augments cell-mediated immune function and transiently suppresses humoral immune function.

Publication ,  Journal Article
Neigh, GN; Glasper, ER; Bilbo, SD; Traystman, RJ; Courtney DeVries, A
Published in: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
November 2005

Immune system activation has implications for cerebrovascular health, but little is known about the function of the immune system after a major cerebrovascular event, such as cardiac arrest and cardiopulmonary resuscitation (CA/CPR). Cardiac arrest and cardiopulmonary resuscitation damages the hippocampus, an important component of the hypothalamic-pituitary-adrenal (HPA) axis, and alterations in HPA axis activity can affect immune function. We tested the hypothesis that CA/CPR (approximately 8 mins) would cause HPA axis dysregulation and alter the delayed type hypersensitivity (DTH) response to antigenic challenge. We also assessed the primary and secondary antibody response of mice exposed to CA/CPR. Of the mice exposed to CA/CPR, half had brains protected by hypothermia to isolate the effects of the CA/CPR procedure from the effects of CA/CPR-induced neuronal damage. Cardiac arrest and cardiopulmonary resuscitation-induced neuronal damage resulted in a persistent elevation of blood corticosterone concentration and a concomitant augmentation of the DTH response to antigenic challenge. Furthermore, immune activation before CA/CPR decreased survival after global ischemia. These data highlight the potential impact of neuronal damage on cell-mediated immune function and the role of humoral immune activation in outcome after global ischemia.

Duke Scholars

Published In

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

DOI

EISSN

1559-7016

ISSN

0271-678X

Publication Date

November 2005

Volume

25

Issue

11

Start / End Page

1424 / 1432

Related Subject Headings

  • Pituitary-Adrenal System
  • Neurons
  • Neurology & Neurosurgery
  • Mice
  • Male
  • Ischemia
  • Immunity, Cellular
  • Hypothermia
  • Hypothalamo-Hypophyseal System
  • Hypersensitivity, Delayed
 

Citation

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MLA
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Neigh, G. N., Glasper, E. R., Bilbo, S. D., Traystman, R. J., & Courtney DeVries, A. (2005). Cardiac arrest/cardiopulmonary resuscitation augments cell-mediated immune function and transiently suppresses humoral immune function. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism, 25(11), 1424–1432. https://doi.org/10.1038/sj.jcbfm.9600137
Neigh, Gretchen N., Erica R. Glasper, Staci D. Bilbo, Richard J. Traystman, and A. Courtney DeVries. “Cardiac arrest/cardiopulmonary resuscitation augments cell-mediated immune function and transiently suppresses humoral immune function.Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism 25, no. 11 (November 2005): 1424–32. https://doi.org/10.1038/sj.jcbfm.9600137.
Neigh GN, Glasper ER, Bilbo SD, Traystman RJ, Courtney DeVries A. Cardiac arrest/cardiopulmonary resuscitation augments cell-mediated immune function and transiently suppresses humoral immune function. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2005 Nov;25(11):1424–32.
Neigh, Gretchen N., et al. “Cardiac arrest/cardiopulmonary resuscitation augments cell-mediated immune function and transiently suppresses humoral immune function.Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism, vol. 25, no. 11, Nov. 2005, pp. 1424–32. Epmc, doi:10.1038/sj.jcbfm.9600137.
Neigh GN, Glasper ER, Bilbo SD, Traystman RJ, Courtney DeVries A. Cardiac arrest/cardiopulmonary resuscitation augments cell-mediated immune function and transiently suppresses humoral immune function. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2005 Nov;25(11):1424–1432.
Journal cover image

Published In

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

DOI

EISSN

1559-7016

ISSN

0271-678X

Publication Date

November 2005

Volume

25

Issue

11

Start / End Page

1424 / 1432

Related Subject Headings

  • Pituitary-Adrenal System
  • Neurons
  • Neurology & Neurosurgery
  • Mice
  • Male
  • Ischemia
  • Immunity, Cellular
  • Hypothermia
  • Hypothalamo-Hypophyseal System
  • Hypersensitivity, Delayed